التفاصيل البيبلوغرافية
| العنوان: |
Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity. |
| المؤلفون: |
LIPING YU1, FRAN DONG1, DONGMEI MIAO1, FOUTS, ALEXANDRA R.1, WENZLAU, JANET M.1, STECK, ANDREA K.1 andrea.steck@ucdenver.edu |
| المصدر: |
Diabetes Care. Aug2013, Vol. 36 Issue 8, p2266-2270. 5p. 2 Charts, 2 Graphs. |
| مصطلحات موضوعية: |
*AUTOANTIBODIES, *PREDIABETIC state, *AUTOIMMUNE diseases, *INSULIN research, *DIABETES |
| مستخلص: |
OBJECTIVE--We evaluated a novel electrochemiluminescent assay for insulin/proinsulin autoantibodies (ECL-IAA) as a new marker of the onset of islet autoimmunity and as a predictor of type 1 diabetes. RESEARCH DESIGN AND METHODS--The Diabetes Autoimmunity Study in the Young (DAISY) prospectively follows children at increased genetic risk for development of islet autoimmunity (defined as presence of autoantibodies to insulin, GAD65, IA-2, or zinc transporter 8 [ZnT8]) and type 1 diabetes (general population of children and first-degree relatives). Serial serum samples from subjects who progressed to type 1 diabetes and who had their first islet autoantibodies measured by age 18 months (N = 47) were tested using ECL-IAA. RESULTS--Almost all prediabetic children tested positive for ECL-IAA (46 of 47, 98%) during follow-up. ECL-IAA was almost always the first autoantibody to appear (94% total; 21 % very first [by itself]; 23% with only mIAA; 19% with another islet autoantibody [GAD or ZnT8]; and 30% with $2 other antibodies [mIAA, GAD, IA-2, or ZnT8]). Among the 46 subjects who were ECL-IAA positive, ECL-IAA antedated the onset of other islet autoantibodies by a mean of 2.3 years (range, 0.3-7.2 years). Both the age of appearance of autoantibody and IAA levels (but not GAD65, IA2, or ZnT8 levels) are major determinants of the age of diabetes onset. CONCLUSIONS--This new ECL-IAA assay defines more precisely the onset of prediabetic autoimmunity and may help identify events triggering islet autoimmunity, as well as allow earlier intervention for type 1 diabetes. Nearly all young children progressing to diabetes are insulin autoantibody positive. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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