التفاصيل البيبلوغرافية
| العنوان: |
Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake. |
| المؤلفون: |
Mietlicki-Baase, Elizabeth G1, Rupprecht, Laura E1, Olivos, Diana R1, Zimmer, Derek J1, Alter, Mark D2, Pierce, R Christopher2, Schmidt, Heath D2, Hayes, Matthew R1 |
| المصدر: |
Neuropsychopharmacology. Aug2013, Vol. 38 Issue 9, p1685-1697. 13p. 6 Graphs. |
| مصطلحات موضوعية: |
*AMYLIN, *AREA postrema, *INGESTION, *MESSENGER RNA, *SUCROSE, *OBESITY treatment |
| مستخلص: |
The ability of amylin, a pancreatic β-cell-derived neuropeptide, to promote negative energy balance has been ascribed to neural activation at the area postrema. However, despite amylin binding throughout the brain, the possible role of amylin signaling at other nuclei in the control of food intake has been largely neglected. We show that mRNA for all components of the amylin receptor complex is expressed in the ventral tegmental area (VTA), a mesolimbic structure mediating food intake and reward. Direct activation of VTA amylin receptors reduces the intake of chow and palatable sucrose solution in rats. This effect is mediated by reductions in meal size and is not due to nausea/malaise or prolonged suppression of locomotor activity. VTA amylin receptor activation also reduces sucrose self-administration on a progressive ratio schedule. Finally, antagonist studies provide novel evidence that VTA amylin receptor blockade increases food intake and attenuates the intake-suppressive effects of a peripherally administered amylin analog, suggesting that amylin receptor signaling in the VTA is physiologically relevant for food intake control and potentially clinically relevant for the treatment of obesity. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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