التفاصيل البيبلوغرافية
| العنوان: |
Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity: A TMS pilot study. |
| المؤلفون: |
Brigo, Francesco1,2 dr.francescobrigo@gmail.com, Bongiovanni, Luigi Giuseppe1, Nardone, Raffaele2,3, Trinka, Eugen3, Tezzon, Frediano2, Fiaschi, Antonio1, Manganotti, Paolo1 |
| المصدر: |
Epilepsy & Behavior. May2013, Vol. 27 Issue 2, p301-306. 6p. |
| مصطلحات موضوعية: |
*VISUAL cortex, *EXCITATION (Physiology), *PHOTOSENSITIVITY disorders, *EPILEPSY, *TRANSCRANIAL magnetic stimulation, *PHOSPHENES |
| مستخلص: |
Abstract: Background: The current understanding of the mechanisms underlying photosensitivity is still limited, although most studies point to a hyperexcitability of the visual cortex. Methods: Using transcranial magnetic stimulation, we determined the resting motor threshold (rMT) and the phosphene threshold (PT) in 33 patients with IGEs (8 with photosensitivity) compared with 12 healthy controls. Results: Eleven controls (92%) reported phosphenes compared with fifteen (46%) patients with idiopathic generalized epilepsy (p=0.015). Phosphenes were reported more frequently among patients with epilepsy with photosensitivity (87.5%) than in patients with active epilepsy without photosensitivity (30.8%) (p=0.038) and patients with epilepsy in remission without photosensitivity (33.3%) (p=0.054); no differences were found between patients with epilepsy with photosensitivity and controls (p=0.648). Resting motor threshold and phosphene threshold were significantly higher among patients with epilepsy (active epilepsy or epilepsy in remission without photosensitivity) compared to healthy controls (p<0.01). Conversely, patients with active epilepsy and photosensitivity had significantly lower values than controls (p=0.03). Conclusions: The marked decrease in PT and the high phosphene prevalence in patients with IGE with photosensitivity indicate a regional hyperexcitability of the primary visual cortex. Results of this study also suggest that the PT may serve as a biomarker for excitability in patients with IGE and photosensitivity. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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