التفاصيل البيبلوغرافية
| العنوان: |
Regulatory Forum Opinion Piece*: Tox21 and Toxicologic Pathology. |
| المؤلفون: |
Bucher, John R.1 |
| المصدر: |
Toxicologic Pathology. Jan2013, Vol. 41 Issue 1, p125-127. 3p. |
| مصطلحات موضوعية: |
*TOXICOLOGY, *HISTOPATHOLOGY, *TOXICOGENOMICS, *ANIMAL models in research |
| مصطلحات جغرافية: |
UNITED States |
| الشركة/الكيان: |
UNITED States. Food & Drug Administration , NATIONAL Institutes of Health (U.S.) |
| مستخلص: |
Tox21 is a transformative effort on the part of several U.S. Federal agencies (the National Toxicology Program/National Institute of Environmental Health Sciences [NTP], the National Institutes of Health (NIH) Chemical Genomics Center/National Human Genome Research Institute [NCGC; now called the NIH Center for Translational Therapeutics, National Center for Advancing Translational Sciences] the Environmental Protection Agency-s (EPA) National Center for Computational Toxicology, and recently the Food and Drug Administration) that are partnering to fundamentally change the science of safety toxicology. These agencies bring a comprehensive suite of capabilities and are working diligently together to develop, evaluate, and ultimately implement a new safety assessment paradigm. Toxicologic pathology has an important ongoing role in establishing the validity of this transformation, and may ultimately benefit as a discipline through an enhanced understanding of chemically induced disease mechanisms. [ABSTRACT FROM AUTHOR] |
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