التفاصيل البيبلوغرافية
| العنوان: |
Favorable Impact of Growth Hormone Treatment on Cholesterol Levels in Turner Syndrome. |
| المؤلفون: |
Kohno, Hitoshi1 kohno.h@jcom.home.ne.jp, Igarashi, Yutaka2, Ozono, Keiichi3, Ohyama, Kenji4, Ogawa, Masamichi5, Osada, Hisao6, Onigata, Kazumichi7, Kanzaki, Susumu8, Seino, Yoshiki9, Takahashi, Hiroaki10, Tajima, Toshihiro11, Tachibana, Katsuhiko12, Tanaka, Hiroyuki13, Nishi, Yoshikazu14, Hasegawa, Tomonobu15, Fujieda, Kenji16, Fujita, Keinosuke17, Horikawa, Reiko18, Yokoya, Susumu19, Yorifuji, Toru20 |
| المصدر: |
Clinical Pediatric Endocrinology. Apr2012, Vol. 21 Issue 2, p29-34. 6p. 2 Charts, 2 Graphs. |
| مصطلحات موضوعية: |
*TURNER'S syndrome, *METABOLIC disorders, *SOMATOTROPIN, *HORMONE therapy, *BLOOD cholesterol, *BODY weight, *HYPERINSULINISM, *THERAPEUTICS |
| مستخلص: |
Background: Patients with Turner syndrome (TS) are prone to having metabolic abnormalities, such as obesity, dyslipidemia, hypertension, hyperinsulinemia and type 2 diabetes mellitus, resulting in increased risks of developing atherosclerotic diseases. Objective: To determine the effect of growth hormone (GH) therapy on serum cholesterol levels in prepubertal girls with TS enrolled in the Turner syndrome Research Collaboration (TRC) in Japan. Patients and methods: Eighty-one girls with TS were enrolled in the TRC, and their total cholesterol (TC) levels before GH therapy were compared with reported levels of healthy school-aged Japanese girls. TC levels after 1, 2 and 3 yr of GH treatment were available for 28 of the 81 patients with TS. GH was administered by daily subcutaneous injections, 6 or 7 times/wk, with a weekly dose of 0.35 mg/kg body weight. Results: Baseline TC levels revealed an age-related increase in TS that was in contrast to healthy girls showing unchanged levels. During GH therapy, TC decreased significantly after 1 yr of GH treatment and remained low thereafter. Conclusions: Girls with untreated TS showed an age-related increase in TC that was a striking contrast to healthy girls, who showed unchanged levels. GH therapy in girls with TS brought about a favorable change in TC that indicates the beneficial impact of GH on atherogenic risk. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder