التفاصيل البيبلوغرافية
| العنوان: |
The Three Dimensions of Functional T-Cell Tolerance: From Research to Practice. |
| المؤلفون: |
Hünefeld, Christian1, Mezger, Markus2, Röcken, Michael3, Röcken, Martin1 |
| المصدر: |
Journal of Investigative Dermatology. Mar2012, Vol. 132 Issue 3 part 1, p508-511. 4p. |
| مصطلحات موضوعية: |
*T cells, *AUTOANTIGENS, *LICHEN planus, *T cell receptors, *AUTOIMMUNE diseases |
| مستخلص: |
In this issue, Paek et al. describe two phenomena. First, they show that intermediate concentrations of a 'transgenic' autoantigen may cause a lichen planus-like autoimmune disease. Second, and more importantly, they show that high doses of peptide antigen suppress the expression of the T-cell receptor and coreceptors, particularly CD8, and that this suppression improves this T-cell-mediated, destructive inflammatory skin disease that is similar to erosive lichen planus. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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