التفاصيل البيبلوغرافية
| العنوان: |
Neonatal jaundice is associated with a small increase in the risk of childhood type 1 diabetes: a meta-analysis of observational studies. |
| المؤلفون: |
McNamee, Maria1, Cardwell, Chris1, Patterson, Chris1 c.patterson@qub.ac.uk |
| المصدر: |
Acta Diabetologica. Feb2012, Vol. 49 Issue 1, p83-87. 5p. 2 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*NEONATAL jaundice, *DIABETES in children, *SCIENTIFIC observation, *BLOOD groups, *HETEROGENEITY, *TYPE 1 diabetes |
| مستخلص: |
Published data on the role of neonatal jaundice as a risk factor for childhood type 1 diabetes mellitus is inconsistent. We aimed to review systematically, the evidence for an increased risk of type 1 diabetes in children diagnosed with neonatal jaundice. A comprehensive search of the published literature was performed to identify studies that had recorded the occurrence of neonatal jaundice in a group of children with type 1 diabetes and in a group of control children. Odds ratios (ORs) were extracted from reports or derived from tabulated data and then combined using a random effects meta-analysis. Data were available from 12 case-control studies and one retrospective cohort study. Overall, there was only weak evidence of an increase in the risk of type 1 diabetes in children who had neonatal jaundice (OR 1.14, 95% CI 0.99-1.32; P = 0.07), and there was some evidence of heterogeneity ( I = 53%, P = 0.01) mainly attributable to one study. An analysis restricted to studies not relying on parental recall showed a stronger, significant relationship (OR = 1.25, 95% CI 1.03-1.51; P = 0.02), although heterogeneity remained. This analysis found evidence of a small but statistically significant increase in childhood type 1 diabetes risk associated with neonatal jaundice but only for studies which used data from obstetric records. Jaundice caused by blood group incompatibility or requiring phototherapy may be associated with a greater increase in type 1 diabetes risk and deserves further study. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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