التفاصيل البيبلوغرافية
| العنوان: |
Pharmacokinetics and tissue penetration of vancomycin continuous infusion as prophylaxis for vascular surgery. |
| المؤلفون: |
Payne, Christopher J.1, Thomson, Alison H.2,3, Stearns, Adam T.1, Watson, David G.3, Zhang, Tong3, Kingsmore, David B.1, Byrne, Dominique S.1, Binning, Alexander S.4 |
| المصدر: |
Journal of Antimicrobial Chemotherapy (JAC). Nov2011, Vol. 66 Issue 11, p2624-2627. 4p. |
| مصطلحات موضوعية: |
*GLYCOPEPTIDE antibiotics, *VANCOMYCIN, *TISSUES, *SURGERY, *ANTIBACTERIAL agents |
| مستخلص: |
Objectives To determine the tissue penetration of vancomycin into perivascular fat and arterial wall during a continuous infusion of vancomycin, given as prophylaxis for vascular surgery. Patients and methods Patients undergoing arterial reconstruction requiring antibiotic prophylaxis were included. Patients received a loading infusion of vancomycin the evening prior to surgery followed by a continuous 24 h infusion, calculated according to renal function. Three peri-operative serum samples and intra-operative perivascular fat and arterial wall samples were collected for vancomycin assay. Results Twenty-eight patients were included. Three serum samples were obtained from all patients, fat samples were available from 27 (96.4%) patients and vessel wall samples were available from 23 (82.1%) patients. Serum vancomycin concentrations were maintained within a relatively narrow range, while fat and arterial wall concentrations were highly variable. Conclusions This study has shown that prophylactic administration of vancomycin with a loading infusion followed by a continuous infusion before and during vascular surgery achieves serum and vascular tissue concentrations that are above the MICs for most common organisms implicated in post-operative graft infection. However, penetration into perivascular fat tissues is poor. [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
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