التفاصيل البيبلوغرافية
| العنوان: |
T cell tolerance towards the fetal allograft |
| المؤلفون: |
Piccinni, Marie-Pierre1,2 mppiccinni@hotmail.com |
| المصدر: |
Journal of Reproductive Immunology. May2010, Vol. 85 Issue 1, p71-75. 5p. |
| مصطلحات موضوعية: |
*T cells, *HOMOGRAFTS, *HLA histocompatibility antigens, *PREGNANCY complications, *MATERNALLY acquired immunity, *ABORTION, *IMMUNOLOGICAL tolerance, *IMMUNOLOGICAL aspects of pregnancy |
| مستخلص: |
Abstract: The conceptus is considered a semi-allograft because of the presence of paternal HLA-C molecules. These alloantigens can be processed by maternal antigen presenting cells, which present them to specific maternal CD4+ T cells. After activation, the maternal CD4+ T cells can become effector decidual CD4+ T cells, which are able to release various cytokines. Th1-type cytokines (IFNγ) that promote allograft rejection may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-10) that inhibit Th1 responses, promote allograft tolerance and therefore may improve fetal survival. A collaborative interaction between the decidual natural regulatory T cells, CD4+ CD25+ Foxp3 T cells and NKT cells in preventing fetal allograft rejection is suggested. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
Academic Search Index |
