التفاصيل البيبلوغرافية
| العنوان: |
Cannabis use in children and adolescents with first episode psychosis: Influence on psychopathology and short-term outcome (CAFEPS study) |
| المؤلفون: |
Baeza, Immaculada1,2 ibaeza@clinic.ub.es, Graell, Montserrat3, Moreno, Dolores2,4, Castro-Fornieles, Josefina1,2, Parellada, Mara2,4, González-Pinto, Ana2,5, Payá, Beatriz6, Soutullo, César7, de la Serna, Elena1,2, Arango, Celso2,4 |
| المصدر: |
Schizophrenia Research. Sep2009, Vol. 113 Issue 2/3, p129-137. 9p. |
| مصطلحات موضوعية: |
*CANNABIS (Genus), *DRUG abuse, *TEENAGERS, *CHILDREN & drugs, *PATHOLOGICAL psychology, *HEALTH outcome assessment, *PSYCHOSES, *DISEASE prevalence |
| مستخلص: |
Abstract: Objective: To know the prevalence of substance use and its relationship with psychopathology at onset and after six months in children and adolescents with first episode psychosis (FEP). Method: 110 FEP patients, aged 9–17, were assessed for substance use, and with the Positive and Negative Syndrome Scale (PANSS) and other psychopathological and general functioning scales at baseline and after a six-month follow-up. Results: Patients'' substance use at baseline was: tobacco (30.9%), cannabis (29.1%), alcohol (21.8%), cocaine (8.2%), amphetamines (2.7%), LSD (1.8%) and opiates (0.90%). Six months later, there was a decrease in patients'' use of cannabis (p =0.004) and other drugs, except tobacco. Patients were divided, according to their baseline cannabis use, into 32 cannabis users (CU) and 78 non-cannabis users (NCU). CU were older (p =0.002) and had higher PANSS positive scores (p =0.002) and lower PANSS negative (p <0.001), PANSS general (p =0.002) and PANSS total (p =0.007) scores than NCU. At six months, CU had significantly lower PANSS positive (p =0.010), negative (p =0.0001), general (p =0.002) and total (p =0.002) scores than NCU. When we divided CU at six months into previous CU (n =16) and current CU (n =15), previous CU had the best outcome, NCU the worst and current CU had an intermediate profile. Conclusions: Cannabis use may be related to higher positive symptom scores for FEP patients, with greater improvement after six months for those who cease using cannabis. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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