التفاصيل البيبلوغرافية
| العنوان: |
T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasis |
| المؤلفون: |
Vultaggio, Alessandra1, Lombardelli, Letizia1, Giudizi, Maria Grazia1, Biagiotti, Roberta1, Mazzinghi, Benedetta1, Scaletti, Cristina1, Mazzetti, Marcello2, Livi, Claudia3, Leoncini, Francesco2, Romagnani, Sergio1,4, Maggi, Enrico1,4 e.maggi@dmi.unifi.it, Piccinni, Marie-Pierre1 |
| المصدر: |
Microbes & Infection. Feb2008, Vol. 10 Issue 2, p166-174. 9p. |
| مصطلحات موضوعية: |
*HIV-positive persons, *PATIENTS, *HIV infections, *AIDS patients |
| مستخلص: |
Abstract: Factors influencing the susceptibility to mucosal candidiasis in HIV-infected patients are not clearly understood. Since in animal models of candidiasis the T helper (Th)1- or Th2-responses are protective or non-protective, respectively, this study was aimed to evaluate the cytokine profile of T-cell response to Candida albicans in the blood and lesional tissues of human immunodeficiency virus (HIV)-infected individuals, suffering, or not, from pseudomembranous oropharyngeal candidiasis (POPC), of HIV-negative women suffering from recurrent vaginal candidiasis (RVC) and of healthy controls. Peripheral blood mononuclear cells from HIV-infected and RVC patients proliferated to C. albicans antigen more than controls. Upon antigen activation, T cells from HIV-infected patients produced low interferon (IFN)-γ, while only T cells from patients with POPC displayed high interleukin (IL)-4 and IL-5 production. POPC-positive patients also showed higher serum IgE levels than POPC-negative patients. T-cell clones generated from the oral mucosa of one HIV-infected patient with POPC produced IL-4, but not IFN-γ (Th2 phenotype), whereas clones obtained from vaginal mucosa from one RVC patient or one healthy donor showed a Th1 profile. These findings, showing a non-protective Th0/Th2 response to C. albicans antigen in the blood and lesional mucosa of HIV-infected patients with POPC, may explain the high susceptibility of candidiasis in these subjects. [Copyright &y& Elsevier] |
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