التفاصيل البيبلوغرافية
| العنوان: |
Repeated administration of diphenyl ditelluride induces hematological disorders in rats |
| المؤلفون: |
Borges, V.C.1, Rocha, J.B.T.1, Savegnago, L.1, Nogueira, C.W. criswn@quimica.ufsm.br |
| المصدر: |
Food & Chemical Toxicology. Aug2007, Vol. 45 Issue 8, p1453-1458. 6p. |
| مصطلحات موضوعية: |
*RATS, *ASPARTATE aminotransferase, *ALANINE aminotransferase, *LACTATE dehydrogenase, *CREATININE, *TRIGLYCERIDES |
| مستخلص: |
Abstract: In the present study, we investigated potential toxic effects of diphenyl ditelluride, as measured by biochemical and hematological parameters. Rats were given a daily dose of 0.3μmol/kg diphenyl ditelluride by subcutaneous route and sacrificed at different times (24 and 48h). Hepatic and renal TBARS levels were changed by diphenyl ditelluride exposure at the dose 0.9μmol/Kg in rats. Diphenyl ditelluride exposure demonstrated an increase in AST (aspartate aminotransferase), ALT (alanine aminotransferase) and LDH (lactate dehydrogenase) activities. Plasma creatinine and urea levels increase after diphenyl ditelluride exposure. Diphenyl ditelluride also produced a significant decrease in plasma triglyceride and cholesterol levels. In contrast, this compound, at all doses tested, induced a marked increase in total leukocyte counts. The present study suggests that diphenyl ditelluride induces hematological disorders and provides evidence for renal and hepatic toxicity in rats. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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