التفاصيل البيبلوغرافية
| العنوان: |
Which factors are associated with adverse prognosis in multiple myeloma patients after surgery? - preliminary establishment and validation of the nomogram. |
| المؤلفون: |
Liu, Jun-Peng1 (AUTHOR), Xu, Zi-Yu1 (AUTHOR), Wu, Yue1 (AUTHOR), Shi, Xiang-Jun2 (AUTHOR), Shi, Ming1 (AUTHOR), Li, Meng1 (AUTHOR), Du, Xin-Ru1 (AUTHOR) duxinru@ccmu.edu.cn, Yao, Xing-Chen1 (AUTHOR) |
| المصدر: |
World Journal of Surgical Oncology. 6/25/2024, Vol. 22 Issue 1, p1-13. 13p. |
| مصطلحات موضوعية: |
*MULTIPLE myeloma, *NOMOGRAPHY (Mathematics), *KARNOFSKY Performance Status, *LOGISTIC regression analysis, *SURVIVAL rate |
| مستخلص: |
Background: To investigate the prognosis of patients with Multiple Myeloma (MM) after surgery, analyze the risk factors leading to adverse postoperative outcomes, and establish a nomogram. Methods: Clinical data from 154 patients with MM who underwent surgery at our institution between 2007 and 2019 were retrospectively analyzed. Assessing and comparing patients' pain levels, quality of life, and functional status before and after surgery (P < 0.05) were considered statistically significant. The Kaplan-Meier survival curve was used to estimate the median survival time. Adverse postoperative outcomes were defined as worsened symptoms, lesion recurrence, complication grade ≥ 2, or a postoperative survival period < 1 year. Logistic regression analysis was used to determine the prognostic factors. Based on the logistic regression results, a nomogram predictive model was developed and calibrated. Results: Postoperative pain was significantly alleviated in patients with MM, and there were significant improvements in the quality of life and functional status (P < 0.05). The median postoperative survival was 41 months. Forty-nine patients (31.8%) experienced adverse postoperative outcomes. Multivariate logistic regression analysis identified patient age, duration of MM, International Staging System, preoperative Karnofsky Performance Status, and Hb < 90 g/L as independent factors influencing patient prognosis. Based on these results, a nomogram was constructed, with a C-index of 0.812. The calibration curve demonstrated similarity between the predicted and actual survival curves. Decision curve analysis favored the predictive value of the model at high-risk thresholds from 10% to-69%. Conclusion: This study developed a nomogram risk prediction model to assist in providing quantifiable assessment indicators for preoperative evaluation of surgical risk. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder