التفاصيل البيبلوغرافية
| العنوان: |
Lipodystrophy Prevalence, "Lipodystrophy-Like Phenotypes," and Diagnostic Challenges. |
| المؤلفون: |
Akinci, Baris1,2 (AUTHOR) barisakincimd@gmail.com, von Schnurbein, Julia3 (AUTHOR), Araujo-Vilar, David4,5 (AUTHOR), Wabitsch, Martin3 (AUTHOR), Oral, Elif A.6 (AUTHOR) eliforal@med.umich.edu |
| المصدر: |
Diabetes. Jul2024, Vol. 73 Issue 7, p1039-1042. 4p. |
| مصطلحات موضوعية: |
*LIPODYSTROPHY, *PHENOTYPES, *ADIPOSE tissues, *MEDICAL record databases, *GENETIC databases |
| مستخلص: |
The article discusses the prevalence of lipodystrophy and lipodystrophy-like phenotypes, which are conditions characterized by altered adipose tissue distribution. The study found that lipodystrophy-like phenotypes are more common than the clinical or genetic prevalence of familial partial lipodystrophy (FPLD), a rare disease. The authors propose using a fat mass ratio (FMR) derived from DEXA scans to identify individuals with lipodystrophy-like phenotypes and potentially develop targeted therapies. However, they emphasize that a comprehensive clinical assessment is necessary for a definitive diagnosis of lipodystrophy syndromes. The article also highlights the challenges in accurately estimating the prevalence of lipodystrophy due to underdiagnosis and the involvement of unidentified genes. Overall, understanding and differentiating lipodystrophy and lipodystrophy-like phenotypes can improve personalized disease management and interventions. [Extracted from the article] |
| قاعدة البيانات: |
Academic Search Index |
