التفاصيل البيبلوغرافية
| العنوان: |
Long-Term Pharmacokinetic Follow-Up of Abiraterone Acetate in Patients with Metastatic Castration-Resistant Prostate Cancer. |
| المؤلفون: |
Chamorey, Emmanuel1 (AUTHOR) jocelyn.gal@nice.unicancer.fr, Pujalte-Martin, Marc2 (AUTHOR), Ferrero, Jean-Marc2 (AUTHOR), Mahammedi, Hakim3 (AUTHOR), Gravis, Gwenaelle4 (AUTHOR), Roubaud, Guilhem5 (AUTHOR), Beuzeboc, Philippe6 (AUTHOR), Largillier, Remy7 (AUTHOR), Borchiellini, Delphine2,8 (AUTHOR), Linassier, Claude9 (AUTHOR), Bouges, Hélène10 (AUTHOR), Etienne-Grimaldi, Marie-Christine10 (AUTHOR), Schiappa, Renaud1 (AUTHOR), Gal, Jocelyn1 (AUTHOR), Milano, Gérard10 (AUTHOR) gerard.milano@nice.unicancer.fr |
| المصدر: |
International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p6058. 11p. |
| مصطلحات موضوعية: |
*CASTRATION-resistant prostate cancer, *ABIRATERONE acetate, *PROSTATE cancer patients, *CANCER patients, *OLDER patients, *DOCETAXEL, *ACETATES |
| مستخلص: |
This ABIGENE pharmacokinetic (PK) study sought mainly to characterize the unchanged drug PK during long-term abiraterone acetate (AA) administration in advanced prostate cancer patients (81 patients). It was observed that individual AA concentrations remained constant over treatment time, with no noticeable changes during repeated long-term drug administration for up to 120 days. There was no correlation between AA concentrations and survival outcomes. However, a significant association between higher AA concentrations and better clinical benefit was observed (p = 0.041). The safety data did not correlate with the AA PK data. A significant positive correlation (r = 0.40, p < 0.001) was observed between mean AA concentration and patient age: the older the patient, the higher the AA concentration. Patient age was found to impact steady-state AA concentration: the older the patient, the higher the mean AA concentration. Altogether, these data may help to guide future research and clinical trials in order to maximize the benefits of AA metastatic castration-resistant prostate cancer patients. [ABSTRACT FROM AUTHOR] |
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