التفاصيل البيبلوغرافية
| العنوان: |
Integrated anti-vascular and immune-chemotherapy for colorectal carcinoma using a pH-responsive polymeric delivery system. |
| المؤلفون: |
Ma, Xiaoqian1 (AUTHOR), Yang, Qing1 (AUTHOR), Lin, Nuo1 (AUTHOR), Feng, Yushuo (AUTHOR), Liu, Yaqing (AUTHOR), Liu, Peifei (AUTHOR), Wang, Yiru (AUTHOR), Deng, Huaping (AUTHOR), Ding, Haizhen (AUTHOR), Chen, Hongmin1 (AUTHOR) hchen@xmu.edu.cn |
| المصدر: |
Journal of Controlled Release. Jun2024, Vol. 370, p230-238. 9p. |
| مصطلحات موضوعية: |
*COLORECTAL cancer, *POLYMERSOMES, *ENZYME-linked immunosorbent assay, *POLYMERS, *TREATMENT effectiveness, *CELL lines |
| مستخلص: |
Colorectal carcinoma (CRC) has become one of the most prevalent malignant tumors and exploring a potential therapeutic strategy with diminished drug-associated adverse effects to combat CRC is urgent. Herein, we designed a pH-responsive polymer to efficiently encapsulate a stimulator of interferon genes (STING) agonist (5,6- dimethylxanthenone-4-acetic acid, termed ASA404) and a common clinically used chemotherapeutic agent (1-hexylcarbamoyl-5-fluorouracil, termed HCFU). Investigations in vitro demonstrated that polymer encapsulation endowed the system with a pH-dependent disassembly behavior (pH t 6.37), which preferentially selected cancerous cells with a favorable dose reduction (dose reduction index (DRI) of HCFU was 4.09). Moreover, the growth of CRC in tumor-bearing mice was effectively suppressed, with tumor suppression rates up to 94.74%, and a combination index (CI) value of less than one (CI = 0.41 for CT26 cell lines), indicating a significant synergistic therapeutic effect. Histological analysis of the tumor micro-vessel density and enzyme-linked immunosorbent assay (ELISA) tests indicated that the system increased TNF-α and IFN-β levels in serum. Therefore, this research introduces a pH-responsive polymer-based theranostic platform with great potential for immune-chemotherapeutic and anti-vascular combination therapy of CRC. [Display omitted] [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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