التفاصيل البيبلوغرافية
| العنوان: |
Modified RobustMeta-Analytic-Predictive Priors for Incorporating Historical Controls in Clinical Trials. |
| المؤلفون: |
Qiang Zhao1 qiang.zhao6@gilead.com, Haijun Ma2 |
| المصدر: |
Statistics in Biopharmaceutical Research. Apr-Jun2024, Vol. 16 Issue 2, p241-247. 7p. |
| مصطلحات موضوعية: |
*CLINICAL trials, *EMPIRICAL Bayes methods |
| مستخلص: |
Incorporating historical information in clinical trials has been of much interest recently because of its potential to reduce the size and cost of clinical trials. Data-conflict is one of the biggest challenges in incorporating historical information. In order to address the conflict between historical data and current data, several methods have been proposed including the robust meta-analytic-predictive (rMAP) prior method. In this article, we propose to modify the rMAP prior method by using an empirical Bayes approach to estimate theweights for the two components of the rMAP prior. Via numerical calculations,we showthat this modification to the rMAP method improves its performance regarding multiple key metrics. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
