التفاصيل البيبلوغرافية
| العنوان: |
A Systematic Review and Meta-Analysis on the Diagnostic and Prognostic Values of 18 F-FDG PET in Uveal Melanoma and Its Hepatic Metastasis. |
| المؤلفون: |
Mirshahvalad, Seyed Ali1,2 (AUTHOR) ali.mirshahvalad@uhn.ca, Zamani-Siahkali, Nazanin1,3 (AUTHOR) nazaninzamanisiahkali@gmail.com, Pirich, Christian1 (AUTHOR) c.pirich@salk.at, Beheshti, Mohsen1 (AUTHOR) m.beheshti@salk.at |
| المصدر: |
Cancers. May2024, Vol. 16 Issue 9, p1712. 14p. |
| مصطلحات موضوعية: |
*MELANOMA diagnosis, *LIVER tumors, *PREDICTIVE tests, *UVEA cancer, *RADIOPHARMACEUTICALS, *DEOXY sugars, *POSITRON emission tomography, *META-analysis, *METASTASIS, *SYSTEMATIC reviews, *CONFIDENCE intervals, *SURVIVAL analysis (Biometry), *SENSITIVITY & specificity (Statistics) |
| مستخلص: |
Simple Summary: Melanoma is the most common primary intra-ocular cancer in adults. In case of suspected extra-ocular tumoral involvement, patients may be required to undergo computed tomography (CT) and magnetic resonance imaging (MRI). Positron emission tomography (PET) with 18F-Fluorodeoxyglucose (18F-FDG) is another imaging modality that can be used in uveal melanoma assessment. Although comprehensive systematic reviews and meta-analyses were published on the role of 18F-FDG PET imaging in cutaneous melanoma, there is no ample evidence regarding its value in uveal melanoma patients. Thus, in this systematic review and meta-analysis, we tried to investigate the existing literature and provide a comprehensive study on the diagnostic and prognostic values of 18F-FDG PET in uveal melanoma. In this systematic review and meta-analysis (PRISMA-compliant), we tried to investigate diagnostic and prognostic values of 18F-FDG PET in uveal melanoma. A systematic search was conducted on the main medical literature databases to include studies that evaluated 18F-FDG PET as the imaging modality to evaluate patients with uveal melanoma. Overall, 27 studies were included. Twelve had data about the detection rate of 18F-FDG PET in primary intra-ocular tumours. The pooled sensitivity was 45% (95%CI: 41–50%). Furthermore, studies showed that the larger the primary tumour, the higher its uptake. Among the included studies, 13 assessed 18F-FDG PET in detecting metastasis. The pooled sensitivity and specificity were 96% (95%CI: 81–99%) and 100% (95%CI: 94–100%), respectively. Regarding liver metastasis, they were 95% (95%CI: 79–99%) and 100% (95%CI: 91–100%), respectively. Noteworthy, the level of 18F-FDG uptake was a strong predictor of patient survival. Lastly, 18F-FDG PET could characterise lesions from the histopathology perspective, distinguishing high-risk from low-risk diseases. Overall, although not reliable in detecting primary intra-ocular tumours, 18F-FDG PET is highly accurate for diagnosing metastatic uveal melanomas. It can also be a highly valuable modality in terms of patient prognostication. Thus, 18F-FDG PET can be recommended in patients diagnosed with uveal melanoma to enhance decision-making and patient management. [ABSTRACT FROM AUTHOR] |
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