التفاصيل البيبلوغرافية
| العنوان: |
Impact of headache frequency and preventive treatment failure on quality of life, disability, and direct and indirect costs among individuals with episodic migraine in the United States. |
| المؤلفون: |
Dodick, David W.1, Reed, Michael L.2, Lee, Lulu3, Balkaran, Bridget L.3, Umashankar, Kandavadivu4, Parikh, Mousam4, Gandhi, Pranav4 pranav.gandhi@abbvie.com, Buse, Dawn C.5 |
| المصدر: |
Headache: The Journal of Head & Face Pain. Apr2024, Vol. 64 Issue 4, p361-373. 13p. |
| مصطلحات موضوعية: |
*CROSS-sectional method, *SELF-evaluation, *JOB absenteeism, *LABOR productivity, *RESEARCH funding, *HEADACHE, *MULTIPLE regression analysis, *SOCIOECONOMIC factors, *HOSPITAL care, *QUESTIONNAIRES, *FUNCTIONAL status, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *HOSPITAL emergency services, *SURVEYS, *QUALITY of life, *TREATMENT failure, *COMPARATIVE studies, *PREVENTIVE health services, *MEDICAL care costs |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
Objective: To evaluate unmet needs among individuals with episodic migraine (EM) in the United States (US). Background: Data are limited on the impact of headache frequency (HF) and preventive treatment failure (TF) on the burden of migraine in the US. Methods: A retrospective, cross‐sectional analysis of 2019 National Health and Wellness Survey (NHWS) data was conducted from an opt‐in online survey that identified respondents (aged ≥18 years) in the US with self‐reported physician‐diagnosed migraine. Participants were stratified by HF (low: 0–3 days/month; moderate‐to‐high: 4–14 days/month) and prior preventive TF (preventive naive; 0–1 TF; ≥2 TFs). Comparisons were conducted between preventive TF groups using multivariable regression models controlling for patient demographic and health characteristics. Results: Among individuals with moderate‐to‐high frequency EM, the NHWS identified 397 with ≥2 TFs, 334 with 0–1 TF, and 356 as preventive naive. The 36‐item Short‐Form Health Survey (version 2) Physical Component Summary scores were significantly lower among those with ≥2 TFs, at a mean (standard error [SE]) of 41.4 [0.8] versus the preventive‐naive 46.8 [0.9] and 0–1 TF 44.5 [0.9] groups; p < 0.001 for both). Migraine Disability Assessment Scale scores were significantly higher in the ≥2 TFs, at a mean (SE) of 37.7 (3.9) versus preventive‐naive 26.8 (2.9) (p < 0.001) and 0–1 TF 30.1 (3.3) (p = 0.011) groups. The percentages of time that respondents experienced absenteeism (mean [SE] 21.6% [5.5%] vs. 13.4% [3.6%]; p = 0.022), presenteeism (mean [SE] 55.0% [8.3%] vs. 40.8% [6.5%]; p = 0.015), overall work impairment (mean [SE] 59.4% [5.6%] vs. 45.0% [4.4%]; p < 0.001), and activity impairment (mean [SE] 56.8% [1.0%] vs. 44.4% [0.9%]; p < 0.001) were significantly higher in the ≥2 TFs versus preventive‐naive group. Emergency department visits (preventive‐naive, p = 0.006; 0–1 TF, p = 0.008) and hospitalizations (p < 0.001 both) in the past 6 months were significantly higher in the ≥2 TFs group. Direct and indirect costs were significantly higher in the ≥2 TFs (mean [SE] $24,026 [3460]; $22,074 [20]) versus 0–1 TF ($10,897 [1636]; $17,965 [17]) and preventive‐naive ($11,497 [1715]; $17,167 [17]) groups (p < 0.001 for all). Results were similar in the low‐frequency EM group. Conclusions: In this NHWS analysis, individuals with more prior preventive TFs experienced significantly higher humanistic and economic burden regardless of HF. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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