التفاصيل البيبلوغرافية
| العنوان: |
Allelic reprogramming of chromatin states in human early embryos. |
| المؤلفون: |
Yuan, Shenli1,2,3,4 (AUTHOR), Gao, Lei2 (AUTHOR) gaol@big.ac.cn, Tao, Wenrong1,5 (AUTHOR), Zhan, Jianhong2,3 (AUTHOR), Lu, Gang4 (AUTHOR), Zhang, Jingye1,5 (AUTHOR), Zhang, Chuanxin1,5 (AUTHOR), Yi, Lizhi2 (AUTHOR), Liu, Zhenbo2 (AUTHOR), Hou, Zhenzhen1,5 (AUTHOR), Dai, Min3 (AUTHOR), Zhao, Han1,5 (AUTHOR), Chen, Zi-Jiang1,5,6 (AUTHOR) chenzijiang@hotmail.com, Liu, Jiang2,3,7 (AUTHOR) liuj@big.ac.cn, Wu, Keliang1,5 (AUTHOR) wukeliang_527@163.com |
| المصدر: |
National Science Review. Mar2024, Vol. 11 Issue 3, p1-14. 14p. |
| مصطلحات موضوعية: |
*HUMAN embryos, *HUMAN chromatin, *DNA methylation, *GERM cells, *EMBRYOS, *IMPRINTED polymers |
| مستخلص: |
The reprogramming of parental epigenomes in human early embryos remains elusive. To what extent the characteristics of parental epigenomes are conserved between humans and mice is currently unknown. Here, we mapped parental haploid epigenomes using human parthenogenetic and androgenetic embryos. Human embryos have a larger portion of genome with parentally specific epigenetic states than mouse embryos. The allelic patterns of epigenetic states for orthologous regions are not conserved between humans and mice. Nevertheless, it is conserved that maternal DNA methylation and paternal H3K27me3 are associated with the repression of two alleles in humans and mice. In addition, for DNA-methylation-dependent imprinting, we report 19 novel imprinted genes and their associated germline differentially methylated regions. Unlike in mice, H3K27me3-dependent imprinting is not observed in human early embryos. Collectively, allele-specific epigenomic reprogramming is different in humans and mice. [ABSTRACT FROM AUTHOR] |
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