دورية أكاديمية

Polyomavirus-positive Merkel cell carcinoma: the beginning of the beginning.

التفاصيل البيبلوغرافية
العنوان: Polyomavirus-positive Merkel cell carcinoma: the beginning of the beginning.
المؤلفون: Wong, Michael K.1 MKWong@mdanderson.org, Yee, Cassian1 cyee@mdanderson.org
المصدر: Journal of Clinical Investigation. 4/15/2024, Vol. 134 Issue 8, p1-2. 2p.
مصطلحات موضوعية: *MERKEL cell carcinoma, *T cells, *MERKEL cells, *IMMUNE checkpoint proteins, *CELL death
مستخلص: Merkel cell carcinoma (MCC) is an aggressive, fast-growing, highly metastatic neuroendocrine skin cancer. The Merkel cell polyomavirus (MCPyV) is an oncogenic driver in the majority of MCC tumors. In this issue of the JCI, Hansen and authors report on their tracking of CD8+ T cells reactive to MCPyV T antigen (T-Ag) in the peripheral blood of 26 patients with MCC who were undergoing frontline anti-programmed cell death protein-1 (anti-PD-1) immunotherapy. They discovered unique T cell epitopes and used the power of bar-coded tetramers to portray immune checkpoint inhibitor-induced immunogenicity as a predictor of clinical response. These findings provide the foundation for therapeutic possibilities for MCC, including vaccines and adoptive T cell-and T cell receptor-driven (TCR-driven) treatments. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
الوصف
تدمد:00219738
DOI:10.1172/JCI179749