التفاصيل البيبلوغرافية
| العنوان: |
Supramolecular coordination platinum metallacycle-based multilevel wound dressing for bacteria sensing and wound healing. |
| المؤلفون: |
Wen-Zhen Li1, Xiao-Qiang Wang1, Ling-Ran Liu2,3, Ju Xiao1, Xin-Qiong Wang4 wangxq@wust.edu.cn, Yu-Yuan Ye1, Zi-Xin Wang1, Mai-Yong Zhu3, Yao Sun5 sunyaogbasp@ccnu.edu.cn, Peter J. Stang6 stang@chem.utah.edu, Yan Sun2 elaine.sun@henu.edu.cn |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America. 4/2/2024, Vol. 121 Issue 14, p1-8. 53p. |
| مصطلحات موضوعية: |
*SPIDER silk, *HEALING, *PHOTOTHERMAL effect, *WOUND healing, *PLATINUM, *WOUND infections |
| مستخلص: |
The exploitation of novel wound healing methods with real-time infection sensing and high spatiotemporal precision is highly important for human health. Pt-based metal-organic cycles/cages (MOCs) have been employed as multifunctional antibacterial agents due to their superior Pt-related therapeutic efficiency, various functional subunits and specific geometries. However, how to rationally apply these nanoscale MOCs on the macroscale with controllable therapeutic output is still challenging. Here, a centimeter-scale Pt MOC film was constructed via multistage assembly and subsequently coated on a N,N'-dimethylated dipyridinium thiazolo[5,4-d]thiazole (MPT)-stained silk fabric to form a smart wound dressing for bacterial sensing and wound healing. The MPT on silk fabric could be used to monitor wound infection in real-time through the bacteria-mediated reduction of MPT to its radical form via a color change. The MPT radical also exhibited an excellent photothermal effect under 660 nm light irradiation, which could not only be applied for photothermal therapy but also induce the disassembly of the Pt MOC film suprastructure. The highly ordered Pt MOC film suprastructure exhibited high biosafety, while it also showed improved antibacterial efficiency after thermally induced disassembly. In vitro and in vivo studies revealed that the combination of the Pt MOC film and MPT-stained silk can provide real-time information on wound infection for timely treatment through noninvasive techniques. This study paves the way for bacterial sensing and wound healing with centimeter-scale metal-organic materials. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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