التفاصيل البيبلوغرافية
| العنوان: |
Fork coupling directs DNA replication elongation and termination. |
| المؤلفون: |
Yang Liu1,2, Zhengrong Zhangding3, Xuhao Liu3, Tingting Gan4,5,6, Chen Ai1,6, Jinchun Wu5,7, Haoxin Liang7, Chen, Mohan7, Yuefeng Guo7, Rusen Lu7, Yongpeng Jiang1,6, Xiong Ji1,6, Ning Gao5,8, Daochun Kong5,9, Qing Li1,10, Jiazhi Hu5,7,11 hujz@pku.edu.cn |
| المصدر: |
Science. 3/15/2024, Vol. 383 Issue 6688, p1215-1222. 8p. 5 Diagrams. |
| مصطلحات موضوعية: |
*DNA replication, *HUMAN chromatin, *EUKARYOTIC genomes, *CHROMATIN, *GENOMES |
| مستخلص: |
DNA replication is initiated at multiple loci to ensure timely duplication of eukaryotic genomes. Sister replication forks progress bidirectionally, and replication terminates when two convergent forks encounter one another. To investigate the coordination of replication forks, we developed a replication-associated in situ HiC method to capture chromatin interactions involving nascent DNA. We identify more than 2000 fountain-like structures of chromatin contacts in human and mouse genomes, indicative of coupling of DNA replication forks. Replication fork interaction not only occurs between sister forks but also involves forks from two distinct origins to predetermine replication termination. Termination-associated chromatin fountains are sensitive to replication stress and lead to coupled forks-associated genomic deletions in cancers. These findings reveal the spatial organization of DNA replication forks within the chromatin context. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
