التفاصيل البيبلوغرافية
| العنوان: |
Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy. |
| المؤلفون: |
Li, Fangling1,2 (AUTHOR) lifanglingcdd@sina.com, Cao, Dongdong1 (AUTHOR) caodongd@shzu.edu.cn, Gu, Wenyi3 (AUTHOR) w.gu@uq.edu.au, Li, Dongmei1 (AUTHOR) cuilin@shzu.edu.cn, Liu, Zhiyong2 (AUTHOR) lidongmei@shzu.edu.cn, Cui, Lin1 (AUTHOR) |
| المصدر: |
International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2932. 19p. |
| مصطلحات موضوعية: |
*KAPOSI'S sarcoma-associated herpesvirus, *GANCICLOVIR, *NANOCARRIERS, *FOLIC acid, *GENE expression, *NUCLEIC acids |
| مستخلص: |
Kaposi's sarcoma-associated herpesvirus (KSHV) can cause a variety of malignancies. Ganciclovir (GCV) is one of the most efficient drugs against KSHV, but its non-specificity can cause other side effects in patients. Nucleic acid miR-34a-5p can inhibit the transcription of KSHV RNA and has great potential in anti-KSHV therapy, but there are still problems such as easy degradation and low delivery efficiency. Here, we constructed a co-loaded dual-drug nanocomplex (GCV@ZIF-8/PEI-FA+miR-34a-5p) that contains GCV internally and adsorbs miR-34a-5p externally. The folic acid (FA)-coupled polyethyleneimine (PEI) coating layer (PEI-FA) was shown to increase the cellular uptake of the nanocomplex, which is conducive to the enrichment of drugs at the KSHV infection site. GCV and miR-34a-5p are released at the site of the KSHV infection through the acid hydrolysis characteristics of ZIF-8 and the "proton sponge effect" of PEI. The co-loaded dual-drug nanocomplex not only inhibits the proliferation and migration of KSHV-positive cells but also decreases the mRNA expression level of KSHV lytic and latent genes. In conclusion, this co-loaded dual-drug nanocomplex may provide an attractive strategy for antiviral drug delivery and anti-KSHV therapy. [ABSTRACT FROM AUTHOR] |
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