التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of a novel three‐step decontamination protocol for titanium‐based dental implants: An in vitro and in vivo study. |
| المؤلفون: |
Costa, Raphael Cavalcante1 (AUTHOR), Takeda, Thais Terumi Sadamitsu1 (AUTHOR), Dini, Caroline1 (AUTHOR), Bertolini, Martinna2 (AUTHOR), Ferreira, Raquel Carla3 (AUTHOR), Pereira, Gabriele3 (AUTHOR), Sacramento, Catharina Marques1 (AUTHOR), Ruiz, Karina Gonzales S.1 (AUTHOR), Feres, Magda3,4 (AUTHOR), Shibli, Jamil A.3 (AUTHOR), Barāo, Valentim A. R.1 (AUTHOR) vbarao@unicamp.br, Souza, Joāo Gabriel S.3 (AUTHOR) jgabriel.ssouza@yahoo.com.br |
| المصدر: |
Clinical Oral Implants Research. Mar2024, Vol. 35 Issue 3, p268-281. 14p. |
| مصطلحات موضوعية: |
*DENTAL implants, *SURFACE cleaning, *IN vivo studies, *IN vitro studies, *ROUGH surfaces, *HAIR removal, *ASEPSIS & antisepsis |
| مستخلص: |
Aim: The aim of the study was to evaluate several mechanical and chemical decontamination methods associated with a newly introduced biofilm matrix disruption strategy for biofilm cleaning and preservation of implant surface features. Materials and Methods: Titanium (Ti) discs were obtained by additive manufacturing. Polymicrobial biofilm‐covered Ti disc surfaces were decontaminated with mechanical [Ti curette, Teflon curette, Ti brush, water–air jet device, and Er:YAG laser] or chemical [iodopovidone (PVPI) 0.2% to disrupt the extracellular matrix, along with amoxicillin; minocycline; tetracycline; H2O2 3%; chlorhexidine 0.2%; NaOCl 0.95%; hydrocarbon‐oxo‐borate‐based antiseptic] protocols. The optimal in vitro mechanical/chemical protocol was then tested in combination using an in vivo biofilm model with intra‐oral devices. Results: Er:YAG laser treatment displayed optimum surface cleaning by biofilm removal with minimal deleterious damage to the surface, smaller Ti release, good corrosion stability, and improved fibroblast readhesion. NaOCl 0.95% was the most promising agent to reduce in vitro and in vivo biofilms and was even more effective when associated with PVPI 0.2% as a pre‐treatment to disrupt the biofilm matrix. The combination of Er:YAG laser followed by PVPI 0.2% plus NaOCl 0.95% promoted efficient decontamination of rough Ti surfaces by disrupting the biofilm matrix and killing remnants of in vivo biofilms formed in the mouth (the only protocol to lead to ~99% biofilm eradication). Conclusion: Er:YAG laser + PVPI 0.2% + NaOCl 0.95% can be a reliable decontamination protocol for Ti surfaces, eliminating microbial biofilms without damaging the implant surface. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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