التفاصيل البيبلوغرافية
| العنوان: |
Evolution of Cardiovascular Findings in Multisystem Inflammatory Syndrome in Children (MIS-C) Across COVID-19 Variants: Common Trends and Unusual Presentations. |
| المؤلفون: |
Khan, Rabia S.1 (AUTHOR) rskhan@mednet.ucla.edu, Ordog, Theadora2 (AUTHOR), Hong, Sandy D.3 (AUTHOR), Schmitz, Anna H.4 (AUTHOR), Thattaliyath, Bijoy5 (AUTHOR), Sharathkumar, Anjali A.6 (AUTHOR) |
| المصدر: |
Pediatric Cardiology. Mar2024, Vol. 45 Issue 3, p552-559. 8p. |
| مصطلحات موضوعية: |
*MULTISYSTEM inflammatory syndrome in children, *LEFT ventricular dysfunction, *SARS-CoV-2, *COVID-19, *CARDIAC magnetic resonance imaging, *CARDIOVASCULAR diseases |
| مستخلص: |
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following COVID-19 infection. Cardiac involvement is common and includes left ventricular systolic dysfunction, cardiac marker elevation, electrocardiogram (ECG) changes, and coronary artery dilation. This single-center retrospective cohort study compares cardiovascular disease between three major SARS-CoV-2 variants and describes the evolution of findings in medium-term follow-up. Of 69 total children (mean age 9.2 years, 58% male), 60 (87%) had cardiovascular involvement with the most common features being troponin elevation in 33 (47%) and left ventricular dysfunction in 22 (32%). Based on presumed infection timing, 61 patients were sorted into variant cohorts of Alpha, Delta, and Omicron. Hospitalization was longer for the Delta group (7.7 days) vs Alpha (5.1 days, p = 0.0065) and Omicron (4.9 days, p = 0.012). Troponin elevation was more common in Delta compared to Alpha (13/20 vs 7/25, p = 0.18), and cumulative evidence of cardiac injury (echocardiographic abnormality and/or troponin elevation) was more common in Delta (17/20) compared with Alpha (12/25, p = 0.013) or Omicron (8/16, p = 0.034). Forty-nine (77%) of the original cohort (n = 69) had no cardiac symptoms or findings beyond 3 months post-hospitalization. Cardiac MRI was performed in 28 patients (between 3 and 6 months post-hospitalization) and was normal in 25 patients (89%). The differences in the variant cohorts may be due to alteration of the immune landscape with higher severity of COVID-19 infection. Despite overall reassuring cardiac outcomes, it is important to note the variability of presentation and remain vigilant with future variants. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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