التفاصيل البيبلوغرافية
| العنوان: |
Persistence of antibodies 5 years after hepatitis B vaccination in preterm birth children: A retrospective cohort study using real‐world data. |
| المؤلفون: |
Qin, Wei1,2 (AUTHOR), Shao, Ling1,3 (AUTHOR), Wang, Jun2 (AUTHOR), Zhang, Huan2 (AUTHOR), Wang, Yao2 (AUTHOR), Zhang, Xiaqing2,4 (AUTHOR), Xie, Shaoyu2 (AUTHOR), Pan, Fan2 (AUTHOR), Cheng, Kai2 (AUTHOR), Ma, Liguo2 (AUTHOR), Chen, Yafei2 (AUTHOR), Song, Jian1 (AUTHOR), Gao, Dawei5 (AUTHOR), Chen, Zhichao5 (AUTHOR), Yang, Wei5 (AUTHOR), Zhu, Rui5 (AUTHOR), Su, Hong1 (AUTHOR) suhong5151@sina.com |
| المصدر: |
Journal of Viral Hepatitis. Mar2024, Vol. 31 Issue 3, p143-150. 8p. |
| مصطلحات موضوعية: |
*PREMATURE labor, *LOW birth weight, *HEPATITIS B vaccines, *CHILDBIRTH, *PREMATURE infants, *BOOSTER vaccines |
| مستخلص: |
Previous studies did not provide substantial evidence for long‐term immune persistence after the hepatitis B vaccine (HepB) in preterm birth (PTB) children. Consequently, there is ongoing controversy surrounding the booster immunization strategy for these children. Therefore, we conducted a retrospective cohort study to evaluate the disparities in immune persistence between PTB children and full‐term children. A total of 1027 participants were enrolled in this study, including 505 PTB children in the exposure group and 522 full‐term children in the control group. The negative rate of hepatitis B surface antibody (HBsAb) in the PTB group was significantly lower than that in the control group (47.9% vs. 41.4%, p =.035). The risk of HBsAb‐negative in the exposure group was 1.5 times higher than that in the control group (adjusted odds ratio [aOR] = 1.5, 95% confidence interval [CI]: 1.1–2.0). The geometric mean concentration (GMC) of HBsAb was much lower for participants in the exposure group compared to participants in the control group (9.3 vs. 12.4 mIU/mL, p =.029). Subgroup analysis showed that the very preterm infants (gestational age <32 weeks) and the preterm low birth weight infants (birth weight <2000 g) had relatively low GMC levels of 3.2 mIU/mL (95% CI: 0.9–11.1) and 7.9 mIU/mL (95% CI: 4.2–14.8), respectively. Our findings demonstrated that PTB had a significant impact on the long‐term persistence of HBsAb after HepB vaccination. The very preterm infants (gestational age <32 weeks) and the preterm low birth weight infants (birth weight <2000 g) may be special populations that should be given priority for HepB booster vaccination. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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