دورية أكاديمية

Severe primary hypothyroidism-related hyperprolactinemia and secondary amenorrhea.

التفاصيل البيبلوغرافية
العنوان: Severe primary hypothyroidism-related hyperprolactinemia and secondary amenorrhea.
المؤلفون: Trandafir, Alexandra-Ioana1, Petrova, Eugenia2, Florescu, Alexandru-Florin3, Cârşote, Mara2 carsote_m@hotmail.com, Nistor, Claudiu4, Petca, Aida5, Petca, Răzvan-Cosmin6, Dumitrașcu, Mihai-Cristian7, Şandru, Florica5
المصدر: Obstetrică şi Ginecologie. oct-dec2023, Vol. 71 Issue 4, p190-194. 5p.
مصطلحات موضوعية: *HYPERPROLACTINEMIA, *CONGENITAL hypothyroidism, *AMENORRHEA, *AUTOIMMUNE thyroiditis, *HORMONE deficiencies, *SYMPTOMS
الملخص (بالإنجليزية): We aim to present an adult female confirmed with severe hypothyroidism due to Hashimoto's autoimmune thyroiditis that was associated with hyperprolactinemia which, combined, led to secondary amenorrhea. Additionally, hypercholesterolemia, anemia and vitamin D deficiency were confirmed, and the patient's electrocardiogram showed flattened T waves. The value of TSH (thyroid stimulating hormone) was unexpectedly high, approximately 100 times upper the normal limit. The patient experienced a progression of clinical manifestations within one year, while she did not seek for medical care. This unexpected severity of thyroid hormones deficiency is rarely found nowadays due to active screening protocols and easy access to thyroid assessment; however, in young individuals, the clinical tolerance to myxedema-associated issues is higher than seen in seniors, thus a delay of diagnosis might be found. Whether this impacts the overall reproductive potential in young females mostly depends on the compliance to lifelong hormonal replacement and surveillance of adequate serum hormonal levels, including during pregnancy. [ABSTRACT FROM AUTHOR]
Abstract (Romanian): Prezentăm cazul unei tinere paciente confirmate cu hipotiroidism sever legat de tiroidita autoimună Hashimoto, asociat cu hiperprolactinemie, care, toate combinate, au condus la amenoree secundară. Adiţional, au fost detectate hipercolesterolemie, anemie şi hipovitaminoză D, iar electrocardiograma a arătat unde T aplatizate. Valoarea TSH-ului (hormonul de stimulare tiroidiană) a fost neaştepat de mare, de aproximativ 100 de ori peste limita superioară a normalului. Pacienta a prezentat progresia manifestărilor clinice în decursul unui an, timp în care nu a fost evaluată medical. Acest nivel sever al deficitului hormonilor tiroidieni este rar identificat în prezent, în contextul protocoalelor de screening active şi al accesului facil la bilanţul tiroidian. Totuşi, la persoanele tinere, toleranţa clinică a mixedemului este mai mare decât la seniori, de aceea poate avea loc o întârziere a diagnosticului. Dacă acesta afectează potenţialul reproductiv la femeile tinere depinde cel mai mult de complianţa la substituţia hormonală pe parcursul vieţii şi de menţinerea unui nivel adecvat al hormonilor, inclusiv pe perioada unei sarcini. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index