التفاصيل البيبلوغرافية
| العنوان: |
Spectrophotometric Determination of Mesalazine Based on Schiff Base Formation with 2,4-dimethoxybenzaldehyde and 3,4-dihydroxybenzaldehyde. |
| المؤلفون: |
Ali, Rasul Jameel1,2 rasul.ali@hmu.edu.krd |
| المصدر: |
ZANCO Journal of Pure & Applied Sciences. 2023, Vol. 35 Issue 5, p119-127. 9p. |
| مصطلحات موضوعية: |
*SCHIFF bases, *MESALAMINE, *CONDENSATION reactions, *AROMATIC aldehydes, *DETECTION limit, *HYDROCHLOROTHIAZIDE |
| مستخلص: |
Two straightforward, fast, easy, accurate, and sensitive spectrophotometric methods were developed to measure mesalazine either in its pure form or in tablet dosage form The proposed procedures, specifically, rely on a condensation reaction between mesalazine and aromatic aldehydes, (method A) and (method B), to produce yellow color Schiff's bases. For methods A and B, the concentration ranges where Beer's relationship was observed were 0.4-10 μg mL-1 with a limit of detection of 0.1070 μg mL-1 and a limit of quantification of 0.1323 μg mL-1, and 2-15 μg mL-1 with a limit of detection of 0.3244 μg mL-1 and 0.4010 μg mL-1, respectively. The recovery percentage was 97.82% to 102.1% and 98.15% to 99.91% for the two proposed methods. The proposed methods have been used successfully to determine mesalazine in their tablet formulations. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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