التفاصيل البيبلوغرافية
العنوان: |
A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans. |
المؤلفون: |
Gregory, Justin M.1 (AUTHOR) justin.m.gregory.1@vumc.org, Kraft, Guillaume2 (AUTHOR), Dalla Man, Chiara3 (AUTHOR), Slaughter, James C.4 (AUTHOR), Scott, Melanie F.2 (AUTHOR), Hastings, Jon R.2 (AUTHOR), Edgerton, Dale S.2 (AUTHOR), Moore, Mary C.2 (AUTHOR), Cherrington, Alan D.2 (AUTHOR) |
المصدر: |
PLoS ONE. 12/22/2023, Vol. 18 Issue 12, p1-16. 16p. |
مصطلحات موضوعية: |
*HIGH-fat diet, *INSULIN resistance, *DOGS, *INSULIN, *TYPE 2 diabetes, *FRUCTOSE, *GLUCOSE tolerance tests, *INSULIN sensitivity |
مستخلص: |
This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered metabolic alterations akin to the precursors of human T2DM, notably insulin resistance and β-cell dysfunction. Following the HFFD intervention, the dogs exhibited a 50% decrease in insulin sensitivity within the first four weeks, paralleling observations in the progression from normal to IGT in humans. Calculations of the insulinogenic index using both insulin and C-peptide measurements during oral glucose tolerance tests revealed a significant and sustained decrease in early-phase insulin release, with partial compensation in the later phase, predominantly stemming from reduced hepatic insulin clearance. In addition, the Disposition Index, representing the β-cell's capacity to compensate for diminished insulin sensitivity, fell dramatically. These results confirm that a HFFD can instigate metabolic changes in dogs akin to the early stages of progression to T2DM in humans. The study underscores the potential of using dogs subjected to a HFFD as a model organism for studying human IGT and T2DM. [ABSTRACT FROM AUTHOR] |
قاعدة البيانات: |
Academic Search Index |