التفاصيل البيبلوغرافية
| العنوان: |
Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin. |
| المؤلفون: |
Tanghetti, Emil A.1 (AUTHOR) et@dermatologyandlasersurgery.com, Zeichner, Joshua A.2 (AUTHOR), Gold, Michael3 (AUTHOR), Sadick, Neil4,5 (AUTHOR), Cook-Bolden, Fran E.4,6 (AUTHOR), Kircik, Leon H.2,7,8 (AUTHOR), Stein Gold, Linda9 (AUTHOR), Weiss, Jonathan10,11 (AUTHOR), Tyring, Stephen K.12 (AUTHOR), Del Rosso, James Q.13,14,15 (AUTHOR), Guenin, Eric16 (AUTHOR) |
| المصدر: |
Journal of Dermatological Treatment. 2023, Vol. 34 Issue 1, p1-8. 8p. |
| مصطلحات موضوعية: |
*OINTMENTS, *ACNE, *FACTORS of production, *QUALITY of life, *SEBUM |
| مستخلص: |
Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequelae. Evaluate efficacy, changes in skin oiliness, and safety with tazarotene 0.045% lotion in participants with moderate-to-severe acne and oily skin. In two phase 3, double-blind, 12-week studies (NCT03168321; NCT03168334), participants aged ≥ 9 years with moderate-to-severe acne were randomized 1:1 to once-daily tazarotene 0.045% lotion or vehicle lotion (N = 1614). This pooled, post hoc analysis included only participants self-categorized with oily skin at baseline on the Acne-Specific Quality of Life questionnaire item 19 (scores: 0 [extremely oily] to 6 [not at all oily]). Inflammatory/noninflammatory lesion counts, treatment success, skin oiliness, treatment-emergent adverse events (TEAEs), and cutaneous safety/tolerability were evaluated. In all participants with oily skin (n = 793), tazarotene provided greater reductions in inflammatory/noninflammatory lesions (p < 0.001, both) and greater treatment success rates versus vehicle (p < 0.01) at week 12. Over two-thirds of polymeric lotion-treated participants had subjective skin oiliness reductions by week 12, with around a third reporting 'low/not' oily skin. Tazarotene TEAE rates were similar to the overall population. Once-daily treatment with tazarotene 0.045% polymeric emulsion lotion may help improve patient-perceived skin oiliness in those with moderate-to-severe acne. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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