التفاصيل البيبلوغرافية
| العنوان: |
Structural and nonstructural proteins of Senecavirus A: Recent research advances, and lessons learned from those of other picornaviruses. |
| المؤلفون: |
Wang, Qianqian1,2 (AUTHOR), Meng, Hailan1 (AUTHOR), Ge, Dong3 (AUTHOR), Shan, Hu1 (AUTHOR), Geri, Letu1,2 (AUTHOR) geriletusy@imau.edu.cn, Liu, Fuxiao1 (AUTHOR) laudawn@126.com |
| المصدر: |
Virology. Aug2023, Vol. 585, p155-163. 9p. |
| مصطلحات موضوعية: |
*PICORNAVIRUSES, *CYTOSKELETAL proteins, *VIRAL nonstructural proteins, *SWINE diseases, *VIRAL replication |
| مستخلص: |
Senecavirus A (SVA) is an emerging virus, causing vesicular disease in swine. SVA is a single-stranded, positive-sense RNA virus, which is the only member of the genus Senecavirus in the family Picornaviridae. SVA genome encodes 12 proteins: L, VP4, VP2, VP3, VP1, 2A, 2B, 2C, 3A, 3B, 3C and 3D. The VP1 to VP4 are structural proteins, and the others are nonstructural proteins. The replication of SVA in host cells is a complex process coordinated by an elaborate interplay between the structural and nonstructural proteins. Structural proteins are primarily involved in the invasion and assembly of virions. Nonstructural proteins modulate viral RNA translation and replication, and also take part in antagonizing the antiviral host response and in disrupting some cellular processes to allow virus replication. Here, we systematically reviewed the molecular functions of SVA structural and nonstructural proteins by reference to literatures of SVA itself and other picornaviruses. • Systematically summarizing characteristics of Senecavirus A (SVA). • Critically reviewing advances in research on all SVA proteins. • Comparing some proteins of SVA with those of other picornaviruses. • Providing perspectives on development of novel diagnostics and vaccines. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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