التفاصيل البيبلوغرافية
| العنوان: |
Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors—A Report of two Cases. |
| المؤلفون: |
Krishnamurthy, Kritika1 (AUTHOR) kritikakrishnamurthy@yahoo.com, Merkulova, Yekaterina1 (AUTHOR), Guzman-Arocho, Yaileen1 (AUTHOR), Rosen, Seymour1 (AUTHOR), Sun, Yue1 (AUTHOR) |
| المصدر: |
International Journal of Surgical Pathology. Aug2023, Vol. 31 Issue 5, p866-871. 6p. |
| مصطلحات موضوعية: |
*SMOOTH muscle, *CELL differentiation, *ADENOMATOID tumors, *HISTOGENESIS, *SMOOTH muscle tumors |
| مستخلص: |
Leiomyoadenomatoid tumors of the epididymis are exceedingly rare biphasic tumors composed of an adenomatoid component in the form of gland-like structures lined by single flat or cuboidal cells admixed with smooth muscle. Radiological and gross findings cannot distinguish leiomyoadenomatoid tumors from the more common classic adenomatoid tumors or leiomyomas, and careful microscopic examination is critical in the identification of this esoteric variant. The histogenesis of this entity remains ambiguous. Common hypotheses include a collision tumor, a variant of an adenomatoid tumor with a smooth muscle component, or an adenomatoid tumor arising in the background of reactive smooth muscle hyperplasia. We present 2 cases of leiomyoadenomatoid tumors with diffuse nuclear WT1 positivity in both the adenomatoid and smooth muscle components, supporting the mesothelial origin of these tumors. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
