التفاصيل البيبلوغرافية
| العنوان: |
Chromatin modules and their implication in genomic organization and gene regulation. |
| المؤلفون: |
van Mierlo, Guido1,2 (AUTHOR), Pushkarev, Olga1,2 (AUTHOR), Kribelbauer, Judith F.1,2 (AUTHOR), Deplancke, Bart1,2 (AUTHOR) bart.deplancke@epfl.ch |
| المصدر: |
Trends in Genetics. Feb2023, Vol. 39 Issue 2, p140-153. 14p. |
| مصطلحات موضوعية: |
*GENETIC regulation, *CHROMATIN, *TRANSCRIPTION factors, *LOCUS (Genetics), *GENE expression |
| مستخلص: |
Cis -regulatory elements (CREs) frequently interact within topologically associated domains to regulate gene expression. Interactions between CREs have been captured by several orthogonal approaches in the form of functional hubs, which we propose to refer to as chromatin modules. Chromatin modules are thought to arise through complex direct and indirect interactions between transcription factors, at least partly in an CTCF/Cohesin-independent manner. Formation of chromatin modules may be aided through condensate formation. Chromatin modules may aid in identifying causal regulatory variants that underlie complex traits. Regulation of gene expression is a complex but highly guided process. While genomic technologies and computational approaches have allowed high-throughput mapping of cis-regulatory elements (CREs) and their interactions in 3D, their precise role in regulating gene expression remains obscure. Recent complementary observations revealed that interactions between CREs frequently result in the formation of small-scale functional modules within topologically associating domains. Such chromatin modules likely emerge from a complex interplay between regulatory machineries assembled at CREs, including site-specific binding of transcription factors. Here, we review the methods that allow identifying chromatin modules, summarize possible mechanisms that steer CRE interactions within these modules, and discuss outstanding challenges to uncover how chromatin modules fit in our current understanding of the functional 3D genome. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
