التفاصيل البيبلوغرافية
| العنوان: |
Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. |
| المؤلفون: |
Yeh, Tzu-Lin1,2 (AUTHOR), Tsai, Ming-Chieh2,3,4 (AUTHOR), Tsai, Wen-Hsuan4 (AUTHOR), Tu, Yu-Kang2 (AUTHOR), Chien, Kuo-Liong2,5 (AUTHOR) klchien@ntu.edu.tw |
| المصدر: |
PLoS ONE. 1/25/2023, Vol. 17 Issue 1, p1-14. 14p. |
| مصطلحات موضوعية: |
*FIXED effects model, *GLUCAGON-like peptide-1 receptor, *GLUCAGON-like peptide-1 agonists, *WEIGHT loss, *GLYCEMIC control, *GLYCOSYLATED hemoglobin |
| مستخلص: |
Aims: To explore the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) on glycemic control and weight reduction in adults. Methods: Databases were searched from August 2021 to March 2022. Data were analyzed using mean difference (MD) values with 95% confidence intervals (CIs). Both random-and fixed-effect models were employed. Heterogeneity was explored using pre-specified subgroup analyses and meta-regression. Structural equation modeling fitting was used for the multivariate meta-analysis. Results: A total of 31 double-blind randomized controlled trials with 22,948 participants were included in the meta-analysis. The MD and 95% CI of the pooled GLP1-RA-induced change in the glycated hemoglobin level was -0.78% (-0.97%, -0.60%) in the random-effects model and -0.45% (-0.47%, -0.44%) in the fixed-effect model, with a high heterogeneity (I2 = 97%). The pooled body weight reduction was -4.05 kg (-5.02 kg, -3.09 kg) in the random-effects model and -2.04 kg (-2.16 kg, -1.92 kg) in the fixed-effect model (I2 = 98%). The standardized pooled correlation coefficient between HbA1c levels and body weight was -0.42. A negative correlation between glycemic control and weight reduction was obtained. Conclusion: Long-acting GLP-1 RAs significantly reduced the glycated hemoglobin level and body weight in adults. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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