التفاصيل البيبلوغرافية
| العنوان: |
A SNP of the COX4I2 gene associated with environmental adaptation in Chinese cattle. |
| المؤلفون: |
Quji, Suolang1 (AUTHOR), Wang, Shikang2 (AUTHOR), Luosang, Danzeng1 (AUTHOR), Li, Zhao1 (AUTHOR), Luobu, Ciren1 (AUTHOR), Zhuoga, Gesang1 (AUTHOR), Li, Fuqiang3 (AUTHOR), Xiao, Zhengzhong4 (AUTHOR), Lei, Chuzhao2 (AUTHOR), Zhuzha, Basang1 (AUTHOR) xzxksbszz@126.com |
| المصدر: |
Gene. Jan2023, Vol. 851, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*CATTLE breeds, *CYTOCHROME oxidase, *CATTLE, *CATTLE breeding, *SINGLE nucleotide polymorphisms, *GENES |
| مستخلص: |
• The study identified that the frequency of the COX4I2 gene allele in cattle may vary in different regions with the environmental factors induding temperature, relative humidity as well as temperature and humidity index. The study may contribute to the understanding of genetic basis of environments-adaptability in Chinese local cattle. • This manuscript performed the correlation analysis between the SNP (rs109072064) of 569 individuals from 34 cattle breeds and the local dlimatic conditions. This manuscript provides valuable information for studying the interaction between genotypes and environmental pressure in cattle. • This study provides basic data for the research of the COX4I2 gene. The COX4I2 gene may be used as the genetic marker and can provide new ideas for breeding heat-tolerant cattle breeds in the future. COX4I2 is an isoform of cytochrome C oxidase subunit IV (COX4), which plays an important role in mitochondrial oxidative phosphorylation. This gene affects heat production and thus affects thermoregulatory capacity in mammals. A splice region variant (rs109072064, NC_037340.1:g.61202988C > T) was identified in COX4I2 by using Ensembl, which transforms the amino acid arginine into cysteine in XP_005214921.1. In this study, we sought to determine the relationship between the mutant locus and the environment in which the cattle are located. We verified that mRNA (XM_005214864.4), which translated XP_005214921.1, is expressed in bovine muscle, fat, heart, liver, kidney, lung and testis tissues. The g.61202988C > T variant was then genotyped in 569 individuals of 34 cattle breeds. Compared with the CC genotype, southern cattle carried more the CT and TT genotypes. Furthermore, the association results carried out that the frequencies of genotypes (CC, CT, TT) and the value of climate parameters (mean annual temperature (T), relative humidity (RH) and temperature humidity index (THI)) were significantly correlated (P < 0.01). Hence, we speculated that the g.61202988C > T variant of COX4I2 gene was associated with the environmental adaptation trait in Chinese cattle and the locus may be considered as a molecular marker for Chinese cattle breeding. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
