التفاصيل البيبلوغرافية
| العنوان: |
STUDIES ON THE ADSORBABILITY OF GRAFT-VERSUS-HOST-REACTIVE LYMPHOCYTES. |
| المؤلفون: |
Rubin, B.1 |
| المصدر: |
Clinical & Experimental Immunology. Jun1975, Vol. 20 Issue 3, p513-525. 13p. |
| مصطلحات موضوعية: |
*LYMPHOID tissue, *LYMPHOCYTES, *ANTIGENS, *LABORATORY mice, *FIBROBLASTS, *SPLEEN |
| مستخلص: |
A certain proportion of normal lymphoid cells from organs of different anatomical origin can react against allogeneic histocompatibility antigens, e.g. they can mediate a graft-versus-host (GVH) reaction. The present study was undertaken in order to obtain information about the antigen-specific receptors on GVH-reactive lymphocytes. We used fibroblast monolayers as cellular immunoadsorbents. The results showed that with the methods employed we could not adsorb specifically GVH-reactive lymphocytes in a reproducible way, irrespective of whether these cells were from normal lymphoid organs like spleen, lymph nodes, thymus and bone marrow, from artificial sources like thymus and spleen of anti-thymocyte antiserum treated mice or from spleens of semi-allogeneic, irradiated, thymocyte-reconstituted mice. The most pronounced effect of adsorption on fibroblast monolayers on normal lymphocytes was a non-specific enhancement of their GVH potential. These findings are discussed on the basis of recent results showing both synergistic and antagonistic effects of T-lymphocyte subpopulations. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder