التفاصيل البيبلوغرافية
| العنوان: |
Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle. |
| المؤلفون: |
Zhu, Bokai1 bzhu@pitt.edu |
| المصدر: |
Physiology. Sep2022, Vol. 37 Issue 5, p272-284. 13p. |
| مصطلحات موضوعية: |
*DATA integrity, *LOGIC, *IMMUNE response, *LITERATURE reviews, *LIVER |
| مستخلص: |
The mammalian liver must cope with various metabolic and physiological changes that normally recur every day and result primarily from rest-activity and fasting-feeding cycles. In this article, I present evidence supporting a temporal compartmentalization of rhythmic hepatic metabolic processes into four main clusters: regulation of energy homeostasis, maintenance of information integrity, immune response, and genetic information flow. I further review literatures and discuss how both the circadian and the newly discovered 12-h ultradian clock work together to regulate these four temporally separated processes in mouse liver, which, interestingly, is largely uncoupled from the liver zonation regulation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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