التفاصيل البيبلوغرافية
| العنوان: |
Proteomic analysis of human natural killer cells: insights on new potential NK immune functions |
| المؤلفون: |
Hanna, Jacob1, Fitchett, Jonathan2, Rowe, Tony2, Daniels, Mark2, Heller, Melissa2, Gonen-Gross, Tsufit1, Manaster, Efrat1, Cho, Samuel Y.2, LaBarre, Michael J.2, Mandelboim, Ofer1 oferman@md2.huji.ac.il |
| المصدر: |
Molecular Immunology. Feb2005, Vol. 42 Issue 4, p425-431. 7p. |
| مصطلحات موضوعية: |
*KILLER cells, *IMMUNE system, *CELLS, *PROTEINS |
| مستخلص: |
Abstract: Applying high-throughput proteomic analysis of mammalian cells can facilitate the identification of a large number of proteins expressed in the examined samples. Moreover, extensive research efforts are being made to perform large-scale characterization of membrane proteins. Here we use mass spectrometry-based proteomic strategy to characterize protein expression in membrane-enriched fractions derived from human NK lymphoma cell line YTS. This query yielded a list of over 1000 identified proteins, and provided us with new insights on NK cell biology. We highlight the expression of CD86 on YTS and its ability to co-stimulate TCR responses of human CD4+ T-cells, providing an unexpected link between innate and adaptive immune systems. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
Academic Search Index |
