التفاصيل البيبلوغرافية
| العنوان: |
Hypoglycemic Activity of Glycyrrhizic Acid and Some of its Derivatives in the Alloxan Diabetes Model in Rats. |
| المؤلفون: |
Baltina, L. A.1 (AUTHOR) baltina@anrb.ru, Sapozhnikova, T. A.1 (AUTHOR), Gabdrakhmanova, S. F.1 (AUTHOR), Makara, N. S.1 (AUTHOR), Khisamutdinova, R. Yu.1 (AUTHOR), Baltina, Jr, L. A.1 (AUTHOR), Petrova, S. F.1 (AUTHOR), Saifullina, D. R.2 (AUTHOR), Kondratenko, R. M.2 (AUTHOR) |
| المصدر: |
Pharmaceutical Chemistry Journal. Jul2021, Vol. 55 Issue 4, p340-344. 5p. |
| مصطلحات موضوعية: |
*ALLOXAN diabetes, *LABORATORY rats, *METHYL formate, *BLOOD sugar, *ACARBOSE |
| مستخلص: |
The hypoglycemic activity of glycyrrhizic acid (GA, I), its trisodium (II) and sodium-dilithium salts (III), and a conjugate with L-methionine methyl ester (IV) was studied using an alloxan diabetes model after peroral administration to male Wistar rats. It was found that GA and its conjugate IV at a dose of 100 mg/kg exhibited hypoglycemic activity and reduced the blood glucose content of the animals by 35.5 and 42.6%, respectively, after 120 min. GA conjugate IV had low toxicity and hypoglycemic activity superior to those of GA and acarbose. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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