التفاصيل البيبلوغرافية
| العنوان: |
Thermoregulation in post-cardiac arrest patients treated with targeted temperature management. |
| المؤلفون: |
Hoeyer-Nielsen, Anne Kirstine1,2 (AUTHOR), Holmberg, Mathias J.2,3,4 (AUTHOR), Christensen, Erika F.1 (AUTHOR), Cocchi, Michael N.2 (AUTHOR), Donnino, Michael W.2 (AUTHOR), Grossestreuer, Anne V.1,2 (AUTHOR) agrosses@bidmc.harvard.edu |
| المصدر: |
Resuscitation. May2021, Vol. 162, p63-69. 7p. |
| مصطلحات موضوعية: |
*BODY temperature regulation, *WATER temperature, *URBAN hospitals, *TEMPERATURE, *DEFIBRILLATORS, *INDUCED hypothermia, *RESEARCH, *THERMOTHERAPY, *BODY temperature, *RESEARCH methodology, *RETROSPECTIVE studies, *MEDICAL cooperation, *EVALUATION research, *TREATMENT effectiveness, *COMPARATIVE studies, *CARDIAC arrest, *RESEARCH funding |
| مستخلص: |
Objective: Evaluate the relationship between heat generation during rewarming in post-cardiac arrest patients receiving targeted temperature management (TTM) as a surrogate of thermoregulatory ability and clinical outcomes.Methods: This is a prospective observational single-centre study conducted at an urban tertiary-care hospital. We included post-cardiac arrest adults who received TTM via surface cooling device between April 2018 and June 2019.Results: Patient heat generation was calculated by multiplying the inverse of the average machine water temperature with time to rewarm to 37 °C and standardized in two ways to account for target temperature variation: (1) divided by number of degrees between target temperature and 37 °C, and (2) limited to when patient was rewarmed from 36 °C to 37 °C. The primary outcome was poor neurologic status, defined as Cerebral Performance Category (CPC) score 3-5, and the secondary outcome was 30-day survival. Sixty-six patients were included: 45 (68%) had a CPC-score of 3-5 and 23 (35%) were alive at 30 days. Besides initial rhythm and arrest downtime, baseline characteristics were similar between outcomes. Heat generation was not associated with poor neurological outcome (CPC 3-5: 6.6 [IQR: 6.1, 7.4] versus CPC 1-2: 6.6 [IQR: 5.7, 7.6], p = 0.89) or survival at 30 days (non-survivors: 6.6 [IQR: 6.6, 7.4] vs. survivors: 6.6 [IQR: 5.7, 8.0, p = 0.78]).Conclusion: Heat generation during rewarming was not associated with neurologic outcomes. However, there was a relationship between poor neurological outcome and higher median water temperatures. Time to rewarm was prolonged in patients with poor neurological outcome. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
