التفاصيل البيبلوغرافية
| العنوان: |
Prey sensing and response in a nematode-trapping fungus is governed by the MAPK pheromone response pathway. |
| المؤلفون: |
Sheng-An Chen1, Hung-Che Lin1, Frank C. Schroeder2,3, Yen-Ping Hsueh1 pinghsueh@gate.sinica.edu.tw |
| المصدر: |
Genetics. Feb2021, Vol. 217 Issue 2, p1-11. 11p. |
| مصطلحات موضوعية: |
*FUNGI physiology, *ANIMAL behavior, *MORPHOGENESIS, *NEMATODES, *ANIMAL experimentation, *CELLULAR signal transduction, *GENES, *GENE expression profiling, *COMMUNICATION, *TRANSCRIPTION factors, *LIPIDS |
| مستخلص: |
Detection of surrounding organisms in the environment plays a major role in the evolution of interspecies interactions, such as predator-- prey relationships. Nematode-trapping fungi (NTF) are predators that develop specialized trap structures to capture, kill, and consume nematodes when food sources are limited. Despite the identification of various factors that induce trap morphogenesis, the mechanisms underlying the differentiation process have remained largely unclear. Here, we demonstrate that the highly conserved pheromoneresponse MAPK pathway is essential for sensing ascarosides, a conserved molecular signature of nemaotdes, and is required for the predatory lifestyle switch in the NTF Arthrobotrys oligospora. Gene deletion of STE7 (MAPKK) and FUS3 (MAPK) abolished nematodeinduced trap morphogenesis and conidiation and impaired the growth of hyphae. The conserved transcription factor Ste12 acting downstream of the pheromone-response pathway also plays a vital role in the predation of A. oligospora. Transcriptional profiling of a ste12 mutant identified a small subset of genes with diverse functions that are Ste12 dependent and could trigger trap differentiation. Our work has revealed that A. oligospora perceives and interprets the ascarosides produced by nematodes via the conserved pheromone signaling pathway in fungi, providing molecular insights into the mechanisms of communication between a fungal predator and its nematode prey. [ABSTRACT FROM AUTHOR] |
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