التفاصيل البيبلوغرافية
| العنوان: |
Persistence of SARS-CoV-2-specific antibodies in COVID-19 patients. |
| المؤلفون: |
Wang, Yanan1 (AUTHOR), Li, Jingjing1,2 (AUTHOR), Li, Huijun1,3 (AUTHOR), Lei, Ping4 (AUTHOR), Shen, Guanxin4 (AUTHOR), Yang, Chunguang1 (AUTHOR) cgyang-hust@hotmail.com |
| المصدر: |
International Immunopharmacology. Jan2021, Vol. 90, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*COVID-19, *IMMUNOGLOBULIN M, *LACTATE dehydrogenase, *SARS-CoV-2, *CHEMILUMINESCENCE immunoassay, *C-reactive protein |
| مستخلص: |
• SARS-CoV-2 specific IgG antibodies were suitable for epidemiologic assessments. • IgM was a predominant predictor for the clinical severity of COVID-19 patients. To better understand humoral immunity following SARS-CoV-2 infection, 114 hospitalised COVID-19 patients with antibody monitored over 8 weeks from symptom onset were retrospectively investigated. A total of 445 serum samples were assessed via chemiluminescence immunoassay. Positive rate of virus-specific IgM reached up to over 80% from the second week to the eighth week after symptom onset, then declined quickly to below 30% in the twelfth week. Concentrations of IgG remained high for at least 3 months before subsequently declining. As compared with the non-severe group, serum IgM level from week 3 to week 8 was significantly higher among the patients with severe clinical symptoms (P = 0.012) but not IgG (P = 0.053). Serum IgM level from week 3 to week 8 was correlated with positive virus RNA test (r = 0.201, P = 0.044), albumin level (r = −0.295, P = 0.003), lactic dehydrogenase (LDH) level (r = 0.292, P = 0.003), alkaline phosphatase (ALP) level (r = 0.254, P = 0.010), C-reactive protein (CRP) level (r = 0.281, P = 0.004) during the same course, while serum IgG level was correlated with age (r = 0.207, P = 0.038). This presented results provide insight into duration of SARS-CoV-2 antibodies and interaction between the virus and host systems. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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