التفاصيل البيبلوغرافية
| العنوان: |
Contrast sensitivity impairment in drug-naïve Parkinson's disease patients associates with early cognitive decline. |
| المؤلفون: |
Hong, Sang Bin1,2 (AUTHOR), Ahn, Jeeyun3 (AUTHOR), Yoo, Dalla1,2 (AUTHOR), Shin, Joo Young3 (AUTHOR), Jeon, Beomseok2 (AUTHOR), Lee, Jee-Young1 (AUTHOR) wieber04@snu.ac.kr |
| المصدر: |
Neurological Sciences. Jul2020, Vol. 41 Issue 7, p1837-1842. 6p. 2 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*CONTRAST sensitivity (Vision), *PARKINSON'S disease, *COGNITION disorders, *ODDS ratio |
| مستخلص: |
Objectives: To investigate the contrast sensitivity function in drug-naïve Parkinson's disease (PD) patients and its predictive value with longitudinal follow-up data. Methods: We included newly diagnosed non-demented PD patients who performed contrast sensitivity test between 2013 and 2014. Contrast sensitivity function at drug-naïve state in PD patients was compared with age-matched normal control data of our center. Correlation between contrast sensitivity function and parkinsonian motor and non-motor features including the Mini-Mental State Exam (MMSE) score at the time of diagnosis were analyzed by linear regression. With longitudinal follow-up data after initiating anti-parkinsonian therapy, the risk conferred on subsequent visual hallucinations and cognitive impairment requiring anti-dementia drugs was analyzed by dichotomizing PD group based on the initial contrast sensitivity function. Results: Forty-eight patients were finally included, and mean follow-up periods were 43 months. Contrast sensitivity function in drug-naïve PD patients was significantly worse than controls. Contrast sensitivity function correlated with sleep disturbance (p = 0.001) and global cognitive status reflected by the MMSE score (p = 0.020). It also associated with further decline in the MMSE during the follow-ups (p = 0.029). Patients with below average contrast sensitivity function at the time of diagnosis showed higher risk of cognitive decline requiring anti-dementia drugs (adjusted odds ratio = 4.68, p = 0.04) and of visual hallucinations (adjusted odds ratio = 12.54, p = 0.04) than those above average function during the follow-up. Conclusion: Contrast sensitivity impairment in drug-naïve PD patients associates with clinical demand for therapeutic intervention of cognitive decline as well as development of visual hallucinations in the early course of the disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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