التفاصيل البيبلوغرافية
| العنوان: |
Antioxidant Peptide AOP-P1 Derived from Odorous Frog Showed Protective Effects Against UVB-Induced Skin Damages. |
| المؤلفون: |
Yin, Saige1 (AUTHOR), Li, Shanshan1 (AUTHOR), Bian, Wenxin1 (AUTHOR), Yang, Meifeng1 (AUTHOR), Liu, Naixin1 (AUTHOR), Hu, Yan1 (AUTHOR), Li, Xiaojie2 (AUTHOR), Wang, Ying3 (AUTHOR), Li, Ziliang4 (AUTHOR) yanmeilizilsm@yahoo.com, Sun, Jun1 (AUTHOR) sunjun6661@126.com, Yang, Xinwang1 (AUTHOR) yangxinwanghp@163.com |
| المصدر: |
International Journal of Peptide Research & Therapeutics. Mar2020, Vol. 26 Issue 1, p557-565. 9p. |
| مصطلحات موضوعية: |
*LACTATE dehydrogenase, *SKIN, *SUPEROXIDE dismutase, *FROGS, *CATALASE, *OXIDATIVE stress |
| مستخلص: |
The protection of skin from photo-damage induced by ultraviolet B (UVB) irradiation has been a research hotspot in recent years and gene-encoded antioxidant peptides from amphibians have aroused great attention. In our previous research, a short peptide AOP-P1 identified from amphibian exerted direct scavenging capacity against free radicals, which implied its possible application in protecting skin against photo-injury. In this research, our results revealed that, on both UVB-irradiative and hydrogen peroxide-induced oxidative stress models established with human immortalized keratinocyte, AOP-P1 could protect cell viability, promote the release of catalase, and decrease levels of lactate dehydrogenase & malondialdehyde. Moreover, AOP-P1 could promote the production of superoxide dismutase and glutathione, alleviate the thickness of epidermis & dermal and the production of light spot & collagen fibers on skin photo-injury animal model induced by UVB irradiation. In summary, our results implied the potential application of AOP-P1 in skin protection against photo-damage and highlighted the amphibian-derived antioxidant peptides as novel development of natural antioxidants for the treatment against photo-injury induced by ultraviolet irradiation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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