التفاصيل البيبلوغرافية
| العنوان: |
Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes. |
| المؤلفون: |
Ronzoni, Stefania1 (AUTHOR) stefania.ronzoni@sunnybrook.ca, D'Souza, Rohan2 (AUTHOR), Shynlova, Oksana3 (AUTHOR), Lye, Stephen3 (AUTHOR), Murphy, Kellie E.2 (AUTHOR) |
| المصدر: |
Journal of Maternal-Fetal & Neonatal Medicine. Oct2019, Vol. 32 Issue 20, p3473-3479. 7p. |
| مصطلحات موضوعية: |
*PREMATURE labor, *PREGNANCY, *PREMATURE rupture of fetal membranes, *GESTATIONAL age, *CHILDBIRTH |
| مستخلص: |
Objective: To compare maternal blood endotoxin activity (EA) in women with preterm premature rupture of membranes (PPROM) with gestational age (GA) matched controls; to evaluate serial EA till birth in PPROM and its correlation with latency to delivery. Methods: We followed singleton preterm pregnancies from admission with PPROM until birth. Uncomplicated, GA-matched pregnancies served as controls. Demographics, birth and neonatal outcomes were collected. EA (EAA™) was assessed serially in PPROM and at study entry in controls. EA was compared using Mann Whitney and Wilcoxon tests, p value <.05 was considered significant. Results: We recruited 20 cases of PPROM and 20 controls. Demographics were similar between groups. Mean GA of PPROM was 29.0 ± 2.2 weeks and median latency was 7.5 (IQR 14.1) weeks. Median EA at admission following PPROM was significantly elevated over controls (0.43 (0.18) versus 0.36 (0.2); p <.02). Overall there was no difference in median EA at admission and in labor (0.43 (0.18) versus 0.33 (0.21); p =.2) following PPROM. However, on comparing cases with latency to delivery ≤7 days (n = 10) versus >7 days (n = 10), there was a significant drop in EA in the latter group (0.44 (0.2) versus 0.34 (0.2); p <.004). Conclusions: EA in PPROM represents a promising biomarker in predicting the clinical evolution of preterm birth. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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