التفاصيل البيبلوغرافية
| العنوان: |
Neonatal outcomes of live births after blastocyst biopsy in preimplantation genetic testing cycles: a follow-up of 1,721 children. |
| المؤلفون: |
He, Hui1 (AUTHOR), Jing, Shuang1 (AUTHOR), Lu, Chang Fu1,2,3 (AUTHOR), Tan, Yue Qiu1,2,3 (AUTHOR), Luo, Ke Li1,3 (AUTHOR), Zhang, Shuo Ping1,3 (AUTHOR), Gong, Fei1,3 (AUTHOR), Lu, Guang Xiu1,2,3 (AUTHOR), Lin, Ge1,2,3 (AUTHOR) linggf@hotmail.com |
| المصدر: |
Fertility & Sterility. Jul2019, Vol. 112 Issue 1, p82-88. 7p. |
| مصطلحات موضوعية: |
*CHILDBIRTH, *FETAL macrosomia, *GENETIC testing, *INTRACYTOPLASMIC sperm injection, *FERTILIZATION in vitro, *PREMATURE labor, *BIOPSY, *BIRTH weight, *LOW birth weight, *BLASTOCYST, *COMPARATIVE studies, *EMBRYO transfer, *GESTATIONAL age, *PREMATURE infants, *RESEARCH methodology, *EVALUATION of medical care, *MEDICAL cooperation, *PREGNANCY, *PREIMPLANTATION genetic diagnosis, *RESEARCH, *RISK assessment, *FLUORESCENCE in situ hybridization, *EVALUATION research, *TREATMENT effectiveness, *PREDICTIVE tests, *RETROSPECTIVE studies |
| الملخص (بالإنجليزية): |
Objective: To investigate whether blastocyst biopsy in preimplantation genetic testing (PGT) increases the risk of adverse neonatal outcomes.Design: Retrospective cohort study.Setting: University-affiliated center.Patients: Live births after blastocyst biopsy combined with frozen ET (PGT group) and frozen blastocyst transfer after in vitro fertilization or intracytoplasmic sperm injection (control group).Intervention(s): Blastocyst biopsy.Main Outcome Measure(s): Gestational age (GA), birth weight (BW), and rates of preterm birth (PB), very preterm birth (VPB), extreme preterm birth (EPB), low birth weight (LBW), very low birth weight (VLBW), and macrosomia.Result(s): No significant differences were observed in the sex ratio, GA, PB, VPB, EPB, BW, or rates of LBW, VLBW, and macrosomia between the PGT and control groups for either singletons or twins. However, the cesarean section rate of the PGT group was significantly higher than that of the control group for twins (adjusted odds ratio, 2.383 [1.079, 5.259]). Regarding fluorescence in situ hybridization-PGT neonates, neonatal outcomes, including GA, BW, and rates of PB, VPB, LBW, and VLBW, did not differ between the different groups of biopsied cells (≥10 group and <10 group) for either the grade B or grade C trophectoderm score subgroups; however, in the grade B trophectoderm score subgroup, the rate of boy babies in the ≥10 group was significantly higher than that in the <10 group (83.3% vs. 40.9%). The association between the number of biopsied cells and GA/BW was not statistically significant.Conclusion(s): Blastocyst biopsy may not add additional risk to neonatal outcomes when compared with a control group. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Desenlace neonatal de recién nacidos vivos tras biopsia de blastocisto en ciclos de diagnóstico genético preimplantacional: seguimiento de 1721 niños Investigar si la biopsia de blastocisto en diagnóstico genético preimplantacional (PGT) aumenta el riesgo de desenlaces neonatales adversos. Estudio retrospectivo de cohortes. Centro universitario. recién nacidos vivos después de biopsia de blastocisto con transfer de embriones congelados (grupo PGT) y después de transfer de blastocisto congelado tras fecundación in-vitro o inyección espermática intracitoplásmica (grupo control). biopsia de blastocisto. Edad gestacional (GA), peso al nacer (BW) y tasas de prematuridad (PB), prematuridad severa (VPB), prematuridad extrema (EPB), bajo peso al nacer (LBW), muy bajo peso al nacer (VLBW) y macrosomia. No se observaron diferencias significativas en proporción de sexos, GA, PB, VPB, EPB, ni en tasas de LBW, VLBW, ni macrosomia entre los grupos PGT y control en embarazos únicos ni en gemelares. Sin embargo, la tasa de cesárea del grupo PGT fue significativamente mayor que del grupo control en embarazos gemelares (razón de momios ajustada, 2.383 [1.079, 5.259]). En cuanto a los neonatos nacidos tras PGT por hibridación fluorescente in-situ, los desenlaces neonatales, incluidos GA, BW, y tasas de PB, VPB, LBW y VLBW, no difirieron entre los grupos según el número de células biopsiadas (grupo > 10 y grupo <10) en los subgrupos de trofectodermo de grado B o grado C. Sin embargo, en el subgrupo de trofectodermo de grado B, la tasa de bebés varones en el grupo de > 10 fue significativamente mayor que la del grupo <10 (83.3% vs. 40.9%). La asociación entre el número de células biopsiadas y GA/BW no fue estadísticamente significativa. La biopsia de blastocisto podría no añadir riesgo adicional al desenlace neonatal comparada con el grupo control. [ABSTRACT FROM AUTHOR] |
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