التفاصيل البيبلوغرافية
| العنوان: |
Supraphysiological doses of glucocorticoids induce remission in a patient with retroperitoneal fibrosis but no effect on the course of Hashimoto's thyroiditis: a discordant mode of action. |
| المؤلفون: |
Shakir, Mohamed K. M.1 mohamed_shakir@hotmail.com, Hoang, Thanh D.1, Johnson, Jeptha T.2, Mai, Vinh Q.1 |
| المصدر: |
Modern Rheumatology Case Reports. Jul2019, Vol. 3 Issue 2, p172-178. 7p. |
| مصطلحات موضوعية: |
*GLUCOCORTICOIDS, *RETROPERITONEAL fibrosis, *AUTOIMMUNE thyroiditis, *THYROID gland, *EMISSION-computed tomography |
| مستخلص: |
Glucocorticoids (GC) are widely used to treat autoimmune diseases. We describe the discordant mode of action of GC in retroperitoneal fibrosis (RPF) and Hashimoto's thyroiditis (HT) in this work. A 48-year-old woman presented with abdominal pain. Detailed evaluation confirmed a retroperitoneal infiltrative lesion. Positron emission tomography (PET) scan revealed a hypermetabolic soft tissue mass within the retroperitoneal area and a diffusely hypermetabolic thyroid gland – TFT normal; TPO Ab >600 IU/mL; TgAb 14.4 I U/mL. Diagnoses of HT and idiopathic RPF were made, and she was treated with prednisone. Abdominal infiltrative process improved; however, thyroid ultrasound and PET scan showed no change in thyroid features. Glucocorticoid treatment resulted in remission of RPF, but not HT. The exact pathophysiological mechanism underlying the non-response to GC treatment in patients with HT remains unknown. Our case exhibits the interesting discordant mode of action of GC in RPF and HT. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
