التفاصيل البيبلوغرافية
| العنوان: |
The protective effects of vernicilignan A, a new flavonolignan isolated from Toxicodendron vernicifluum on SH-SY5Y cells against oxidative stress-induced injury. |
| المؤلفون: |
Li, Meichen1 (AUTHOR), Fan, Yanhua1 (AUTHOR), Zhong, Ting1 (AUTHOR), Yi, Ping1 (AUTHOR), Fan, Chengcheng1 (AUTHOR), Wang, Andong1 (AUTHOR), Liu, Jianyu1 (AUTHOR) burningice@126.com, Xu, Yongnan1 (AUTHOR) ynxu@syphu.edu.cn |
| المصدر: |
Fitoterapia. Apr2019, Vol. 134, p81-87. 7p. |
| مصطلحات موضوعية: |
*PROTEIN metabolism, *APOPTOSIS, *CELL culture, *CELL lines, *CELLULAR signal transduction, *CHROMATOGRAPHIC analysis, *FLAVONOIDS, *HIGH performance liquid chromatography, *HYDROGEN peroxide, *LACTATE dehydrogenase, *MEDICINAL plants, *NEURODEGENERATION, *NUCLEAR magnetic resonance spectroscopy, *RESEARCH funding, *STAINS & staining (Microscopy), *THIN layer chromatography, *WESTERN immunoblotting, *PLANT extracts, *OXIDATIVE stress, *CELL survival |
| مستخلص: |
In this study, a new flavonolignan vernicilignan A was isolated from Toxicodendron vernicifluum. The neuroprotective effects of this compound against H 2 O 2 induced cell injury in SH-SY5Y cells were evaluated by MTT assay and LDH release assay. Vernicilignan A dose-dependently attenuated the cell injury and LDH release induced by H 2 O 2 in SH-SY5Y cells. Further study indicated that vernicilignan A reduced cell apoptosis caused by H 2 O 2 treatment via regulation of some apoptotic related proteins including Bax, Bcl-2, caspase 3 and caspase 9. Also, vernicilignan A increase the cell viability of H 2 O 2 treated cells via the activation of Akt and GSK3β. Base on the findings, vernicilignan A exhibited neuroprotective effects through the activation of PI3K/Akt signaling and inhibition of mitochondria apoptosis pathway. Vernicilignan A might be a promising therapeutic agent for oxidative stress induced neurodegenerative diseases. Unlabelled Image [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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