التفاصيل البيبلوغرافية
| العنوان: |
Effects of Preventive Treadmill Exercise on the Recovery of Metabolic and Mitochondrial Factors in the 6-Hydroxydopamine Rat Model of Parkinson's Disease. |
| المؤلفون: |
Rezaee, Zeinab1 (AUTHOR), Marandi, Sayed Mohammad1,2 (AUTHOR) s.m.marandi@spr.ui.ac.ir, Alaei, Hojjatallah3,4 (AUTHOR) alaei@med.mui.ac.ir, Esfarjani, Fahimeh1 (AUTHOR), Feyzollahzadeh, Sadegh5 (AUTHOR) |
| المصدر: |
Neurotoxicity Research. May2019, Vol. 35 Issue 4, p908-917. 10p. |
| مصطلحات موضوعية: |
*TREADMILL exercise, *COOLDOWN, *PARKINSON'S disease, *TREADMILLS, *REDUCING exercises, *PEROXISOME proliferator-activated receptors |
| مستخلص: |
Metabolic and mitochondrial dysfunction has been implicated in Parkinson's disease, while exercise can induce essential pathways of mitochondrial biogenesis. Here, we tested whether long-term preventive treadmill training (16 weeks, 21 m/min, and 0° inclinations for 50 min/d, 5 d/week) effects the mitochondrial and neurodegeneration markers, in the striatum of rats in the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. Following 16 weeks of exercise or no exercise period (n = 16 rats per group), the animals were divided into four experimental groups (n = 8 per group): (1) no exercise and saline (SED), (2) exercise and saline (EX), (3) no exercise and 6-OHDA (SED + 6-OHDA), and (4) exercise and 6-OHDA (EX + 6-OHDA). For the model, 8 μg of 6-OHDA (2 μg/μL prepared in a solution of 0.2% ascorbic acid and 0.9% saline) was injected into the right medial forebrain bundle. Exposure to 6-OHDA resulted in a significant reduction (P < 0.05) of mitochondrial factors AMP-activated protein kinase, peroxisome proliferator-activated receptor gamma coactivator-1 alpha, and tyrosine hydroxylase, and increased expression of silent information regulator T1, mitochondrial transcription factor A, and p53 in the SED + 6-OHDA group relative to SED group. By contrast, gene and protein expressions upon exercise were higher and p53 protein level was lower in the EX + 6-OHDA group compared with SED + 6-OHDA. Further, exercise reduced the extent of weight loss associated with the 6-OHDA injection. In conclusion, exercise might be used to reduce mitochondrial disorders in Parkinson's disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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